30+ Best Nootropics For Mood & Stress Support

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Just as whole foods provide key nutrients for a healthy mood, nootropics supplements can affect different mood states and their associated consequences.

Besides well-known effects on memory and focus, dozens of nootropics are also mood boosters and help regain motivation.

Although someone with serious clinical depression or specific anxiety disorders – such as obsessive-compulsive disorder – must primarily seek medical attention, there is a way for individuals with temporary changes in mood to find help in nootropic supplements.

For some really tense people the best nootropics for mood and mental stress can alleviate tension.

Here is the list of 30+ nootropics, nutrients and nutraceuticals that have a scientific basis in use as mood enhancers.

Table of Contents

How mood enhancers work?

Nootropics for mood and stress work directly or indirectly to affect the activity and signaling of neurotransmitters, hormones, and other signaling molecules, altering brain energetics, neurogenesis, synaptic plasticity, and more. 

They may do so through being neurotransmitters and hormones, affecting their synthesis, reuptake, and signaling, affecting inflammatory signaling, ion channel function, protecting neurons, and more.

Main neurotransmitters for enhancing mood

While neurotransmitters imbalance is not the only cause for various mood disorders, these categories of chemicals are generally considered the main players and mood enhancers:

Dopamine – it pulls us towards enjoyable experiences and helps with reinforcement motivating us to do something repeatedly. Those with the mood problems may possibly have diminishing dopamine levels or be dopamine deficient. Read more on dopamine supplements.

Serotonin – often called the “happy molecule”, this brain chemical is responsible for some of our body’s most important functions such as sleep, appetite, and digestion. If you’d like a mood support from time to time, or are just trying to be more productive at work, an adequate supply of serotonin can have a big impact. Read more on serotonin nootropics.

Acetylcholine – a critical brain chemical for encoding new memories, concentration, cognition and growth of new synapses (neuroplasticity). Early discoveries suggest a role for acetylcholine in the pathophysiology of mood disorders. Read the study of cholinergic regulation of mood.

Oxytocin – this is a ‘cuddle hormone’ that functions as neurotransmitter in the brain and it’s released during our social interactions. Oxytocin in sprays or pills has the power to regulate mood, to improve trust between people and make them more generous. Read more about oxytocin.

Are nootropics safe?

Picture of a hand emerging from the sea holding a sprinkler; how mood enhancers work
You can’t always be sure what you’re getting and whether it’s safe.

All effective drugs may produce adverse side effects, and herbal medicines are no exception.

While best natural nootropics, in general, are extremely safe, some herbal and dietary supplements can have adverse side effects and even cause liver injury.

That’s sometimes due to a variation of active ingredients levels in the products.

And sometimes due to the fact that mood enhancers can interfere with antidepressant medications in the SSRI, SNRI, tricyclic and tetracyclic classes. That can cause dangerous interactions.

The manufacturing methods of producing herbal supplements also can vary in the number of relevant compounds. So it is much safer when you use standardized nootropics extracts.       

The last thing to watch is how well is the supplement absorbed in your body. Does it cause stomach issues for those with gut sensitivities?

Since we have different body chemistry, you may experience mild to adverse side effects if the ingredients are not well-tolerated in your body.

Some side effects include:

  • Digestive issues
  • Headaches
  • Dizziness
  • Nausea
  • Insomnia

You can’t always be sure what you’re getting and whether it’s safe.

If you want to start a healthy nootropic regimen, look for reliable vendors to buy nootropics online.

Best nootropics for mood support

In a narrower sense, we can classify a few types of nootropics that can do the trick when enhancing mood.

  • Herbal nootropics
  • Amino acids
  • Nootropic extracts
  • Synthetic OTC nootropics
  • Racetams
  • Pharmaceutical grade nootropics

We’ll start with the herbal extracts and natural nootropics, at the end of the list are synthetics and pharmaceutical-grade stuff.

DNA chain nootropics for mood ebhancement
The best 30+ nootropics for mood and stress support

1. St. John's wort

Picture of Yellow flowers of St. John's Wort plant

St. John’s wort is probably one of the most recognized natural nootropics for treating depression and mood disorders. The use of St. John’s wort dates back to the moment of the ancient Greeks, as the Hippocrates recorded its medical use. It has long been known in folk medicine for healing properties. The official medicine also attaches importance to it, and various studies prove its pharmacological effects in mood disorders.

2. Kanna Extract

Close up of Kanna flowerKanna (Sceletium tortuosum) is native to South Africa and traditionally is used to improve mood, find support for fatigue and stress. It is not known to be hallucinogenic or to create habits. Local people take it before stressful events like hunting because of its cognitive-enhancing effects. Although there are currently insufficient trials to recommend it, the popularity of Kanna to reduce anxiety and antidepressant effects has led to one effective product. A supplement called Zembrin has all the concentrated qualities of Kanna.

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The Zembrin form of Sceletium extract works by increasing levels of serotonin in your body. Serotonin is most well-known for playing a part in regulating mood and contributing to happiness and general well-being.

By inhibiting PDE4, Zembrin enhances the availability of cAMP molecules, leading to positive effects on mood and memory.

3. Ashwagandha

Picture of green leafs of Aswagandha plant

Ashwagandha (Withania somnifera), or winter cherry, is an important medicinal plant that has been used in the traditional medicine of Ayurveda. In Sanskrit, ashva means “horse” and gandha means “smell”. Its root has a horsey smell and is said to confer the strength and virility of a horse. Various parts of the plant are used, but the most common in supplements is an extracts of its root.

These extracts usually vary between 2%-10% withanolides, its main active compound. Some products like the Shoden® Ashwagandha Extract Capsules by Nootropics Depot goes a big step further in putting a whopping 35% withanolides. In the context of this article, they can help maintain healthy stress levels. But, also may have many unique benefits.

A number of studies suggest anti-anxiety effects, but in the context of chronic stress and anxiety disorder. It has less potency in standard forms of non-stress-related anxiety. However, more research is needed before we can have much confidence or know the optimal dose of this great nootropic for stress support.

4. Kava Kava

Picture of Kava Kava leaves

Kava Kava (lat. Piper methysticum), is a peppermint family plant culture from the North Pacific islands such as Fiji and Tonga. It contains substances called kavapyrones that make people feel calm, relaxed, and happy. In local tradition, Kava is used for medical, religious, and social purposes as a drink with sedative, anesthetic, and hypnotic properties. Maybe a good nootropic for cognition related to mood. Though not completely safe.

In human trials, it appears to be quite reliable and effective in treating nonpsychotic anxiety, and by its reduction depressive symptoms have been reduced too. The increase in well-being seems to be quite large, but secondary to a decrease in anxiety.

5. Saffron

Close up of Saffron floweSaffron is a plant of the iris family that grows wild in Europe. However, today it is so valued that it is cultivated in large quantities, and is also planted as an ornamental plant and spice. Saffron is gaining popularity after the study that gave comparable results to those of Ritalin in ADHD Treatment. In essence, it has an antidepressant action by increasing the levels of dopamine and norepinephrine.

Saffron extract

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The Saffron flower contains a lot of active plant substances that can have medicinal properties. All of these compounds can function as free radical scavengers.

Although scientists believe that saffron can reduce appetite due to the fact that it improves mood, which neutralizes the occurrence of impulsive food intake, saffron is not the only means to reduce weight.

6. Magnolia officinalis

picture of Magnolia bark

The Magnolia Officinalis tree is one of 200 species of magnolia whose aromatic bark is used in traditional Chinese practice due to its unique calming effects. Among 250 ingredients found in Magnolia Bark, Honokiol and Magnolol produce the bulk of their benefits. Both compounds appear to be quite good at regulating stress management, mood, and sleep. They help promote positive mood via regulating serotonergic activity and neuroplasticity in the brain. A very deep sense of relaxation comes from interacting with GABA signaling.

However, optimal doses of magnolia have not been set for any condition. So the quality of supplements can vary greatly from manufacturer to manufacturer, who proclaiming their benefits. You can look here for a Magnolia Bark extract standardized for a whopping 80% Magnolol + Honokiol content.

7. Lemon Balm (Melissa officinalis)

Lemon balm

This plant smeels like a Heaven full of lemons. Can’t really describe it…but it smeels like the best lemon-flavoured candy in the world.

– reviewer

Lemon balm is a perennial herb in the mint family that’s native to Southern Europe and the Mediterranean regions. Studies have shown Lemon Balm to be helpful to the body in maintaining a positive mood. Research says Lemon Balm in a single dose increases the reported “calmness” rating and aid in better cope with psychological and emotional stress.

In nootropic stacks, it works similar to L-theanine and makes a balance in the formulations. It goes complementary with Valerian to assists with the reduction of mental stress.

Read about an interesting new premade nootropic stack that uses it in its formula.

8. L-tyrosine & N-acetyl-tyrosine (NALT)

Tyrosine is one of the most effective nootropics for mood and stress. It’s a non-essential amino acid that plays an important role in the production of the neurotransmitters dopamine and norepinephrine which affect mood, sleep, and concentration.

Several studies have focused on how tyrosine can help reduce stress. They showed a positive correlation between tyrosine supplementation and increased mental performance.

The main effects of L-tyrosine under investigation are acute effects in preventing a decline in cognitive functions in response to physical stress. Tyrosine is of great interest to the military, in response to cold stress, a combination of cold stress and high-altitude stress, prolonged vigilance, and negative body pressure stress.

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Many biohackers like to use N-Acetyl-L-Tyrosine (NALT) form, which is better soluble in water, but has a low rate of conversion to tyrosine in the body. Therefore, it is recommended to give preference to the free form of tyrosine.

9. L-theanine

pictures of green teaA natural substance found in green tea, L-theanine is an amino acid and an extremely popular mild nootropic that is also considered a mood enhancer. L-Theanine has structural similarity to glutamine and both neurotransmitters that are produced from it (GABA and glutamate). The studies suggest a notable increase in relaxation, usually without sedation. Also, the potential reduction in anxiety has been noted in various studies (not consistent) and a notable reduction in response to acute stress.

A favorite in the nootropic stacks because of a stabilizing effect, L-theanine is probably most recognizable when paired with caffeine, like in the Smart Caffeine.

10. Agmatine

Agmatine is obtained from the common amino acid L-arginine, which is involved in protein synthesis. Agmatine is considered a neurotransmitter or neuromodulator which could explain some of its nootropic and adaptogenic effects with primary mood support function.

The clinical antidepressant effect of Agmatine by inhibitory modulation of glutamatergic excitatory transmission will serve as a basis for future pharmacological studies of antidepressants.

This Agmatine sulfate capsules are a great stacker with other nootropics and help to maintain tolerances to other substances.

11. Cannabidiol (CBD)

Cannabis plants for cannabidiol (CBD)Cannabidiol (CBD) was isolated from cannabis by American chemist Roger Adams in 1940, but it was only in recent years that it was promoted into a modern panacea. While there are no long-term human anxiety trials that exist, CBD became very popular for its well-known mood support effects.

It appears that CBD impacts a variety of receptors in the body involved in pain and stress response, including the 5-HT1a serotonin receptor, which affects a variety of mood-enhancing conditions.

In addition to its nootropic benefits, it is accepted that CBD reduces anxiety by altering the GABA-A receptor in such a way as to potentiate the natural calming effect of GABA.

CBD status is a Novel Food in EU while FDA stating that it is not a supplement.

12. Rhodiola Rosea

close-up of yellow rhodiola rosea plants

Rhodiola is considered one of the best natural nootropics. Traditionally, is being used as an anti-fatigue agent and adaptogen compound. Overall, it appears to be a highly serotonergic compound that has mild mood-boosting benefits. Golden Root contains 140 useful compounds, with the main being rosavins and salidrosides.

Rhodiola’s holistic mood-boosting products provide general health benefits and stress relief effects when standardized to 3% rosavins. Daily use of Rhodiola for fatigue and anti-stress is in the range of 288-680 mg. A great nootropic stack Qualia Mind uses it that way in its formula at 300 mg.

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For anti-fatigue and stimulating properties, you want to use a Rhodiola Rosea extract standardized to 3% salidroside. Then it is effective in doses even as low as 50 mg.

As seen in one of the best nootropic formulations, Mind Lab Pro, which takes advantage of the Rhodiola dose-dependent curve.

13. Lion’s Mane Mushroom

Picture of culinary Lion's mane mushroomsLion’s Mane (Yamabushitake) is an edible fungus from Japan and China that looks reminiscent of the mane of a wild cat. It is equally used in medicine and cooking, so in addition to restoring neurons, it serves as a culinary specialty.

In 1991, the Japanese managed to extract the active ingredient Cyathane which stimulates the production of NGF (nerve growth factor). NGF is a protein that protects existing brain cells and even promotes brain cell formation. It also has a role in reducing symptoms of depression.

New research suggests that Lion’s Mane may alleviate irritability, anxiety, and depression due to its beneficial effects on the autonomic nervous system. Studies have found a reduction in anxiety, but also a reduction in the symptoms of depression.

14. PEA (Palmitoylethanolamide)

Palmitoylethanolamide, also known as PEA, is an endocannabinoid-like lipid that is endogenously synthesized in various body fluids and cell types, such as immune cells, neurons, and microglia to fight pain and inflammation. It also exerts a physiological function related to metabolic and cellular homeostasis.

PEA is considered an immunity supplement, and a potent mood enhancer.

One study found that around 60% of individuals with low moods reported mood improvements when they took PEA supplements. Studies show that patients suffering from low mood have lower levels of PEA (and substances produced by the breakdown of PEA) in the blood and other body fluids. 

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PEA is released during exercise, so this could be the reason why exercise makes us feel so good! And it’s an effective post-workout supplement.

15. S-Adenosyl-L-Methionine (SAMe)

This supplement is derived from the amino acid methionine, which means you also consume it when you eat food sources of protein.

There is evidence that SAMe can improve symptoms of depression. After a build-up period of 1-2 months, supplemental SAMe at 800-1600 mg daily appears to be as potent as some pharmaceutical options for depression.

It has been observed to enhance SSRI therapy and SAMe monotherapy and appears to be similar in some studies to tricyclic antidepressants.

16. N-Acetyl L-Cysteine (NAC)

NAC is basically a powerful free radical scavenger and a prodrug for L-cysteine ​​that is a precursor to endogenous glutathione. It increases the body’s antioxidant capacity and balances excitatory and inhibitory neurotransmitters in the brain. Studies found it results in a reduction of depressive symptoms in psychiatrist disorders.

This remarkable supplement, among other things, regulates the amount of glutamate and dopamine in your brain. Although there are no robust trials on humans yet, the inflammatory-modulating effects of NAC may be important for its mood-stabilizing effect. 

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As a caution notice, just like every antioxidant nutrient, NAC in restorative doses (as low as 1.2 g day-to-day) can potentially have pro-oxidant activity. Therefore, it is not suggested in the lack of a considerable validated oxidative stress.

For healthy and balanced individuals that have an optimized glutathione level, the most logical suggestion is to cycle off NAC or otherwise not exaggerate it. Find more in our A-Z guide to NAC benefits.

17. Fish oil (Omega-3)

picture of Omega-3 capsulesA study conducted at the University of Pittsburgh found that people who have lower levels of omega-3 fatty acids in their blood are more likely to be negative and impulsive in their attitudes and feel mild to moderately depressed. Unlike people who have higher values of omega-3 fatty acids. For moderate mood fluctuations, it is good to take an omega-3 choice.

Currently, there is not enough high-quality evidence to determine the effects of omega-3 fatty acids as a therapy for major depressive disorder. Small to moderate positive effects of omega-3 fatty acids were found compared to placebo, but the level of this effect is probably of no major importance to people with depression. And the evidence is low or very low quality with many differences between studies.

18. Tryptophan

picture of dark chocolade rich in tryptophan

Tryptophan is one of the many amino acids found in foods that contain protein. In the body, tryptophan hydroxylase is converted into a molecule called 5-HTP (5-hydroxy-tryptophan) which is used to produce serotonin, melatonin, and niacin (Vitamin B3). The action of tryptophan supplements for the purpose of treating mainly depressive states is based precisely on this metabolic pathway.

The researchers found that anxiety, tension, and feelings of nervousness were greater when participants had tryptophan levels lower than normal

Serotonin regulates our feeling of well-being and happiness. You can test it by eating chocolate, which is rich in tryptophan (contains up to 18 milligrams per ounce) that enters the brain at a rapid rate.

19. Phenylalanine

Phenylalanine is involved in the construction of proteins and belongs to the group of essential amino acids. It is a precursor to tyrosine in your brain. Tyrosine helps in the formation and utilization of dopamine, epinephrine, norepinephrine, and melatonin.

The antidepressant action of individual phenylalanine supplements is based on the assumption that they affect the concentration of dopamine and norepinephrine, the balance of which is disturbed in depressed states of the body.

Numerous studies on this topic in the United States were done in the 1970s and 1980s, but further research is needed to prove the antidepressant effect of this amino acid.

Some classic ready-made supplements use Phenylalanine in good quantities. Read our CILTEP nootropic stack review

20. 5-HTP

As a direct precursor, 5-HTP affects the increase in the levels of serotonin which makes us satisfied and motivated. Its supplementation has been shown to be more effective than tryptophan itself for this purpose.

5-HTP is used in clinical trials of drugs that affect serotonin levels. It is a safe alternative to antidepressants from the SSRI group (serotonin reuptake inhibitors). Without the advice of a psychiatrist, do not write the treatment protocols on your own.

21. Brahmi (Bacopa Monnieri)

Close upa of the Bacopa Monnieri flowersBacopa Monnieri is known as one of the best nootropics for studying and learning. It affects the increase of certain chemicals in the brain that are important for the successful performance of cognitive functions such as thinking, learning, and memory. Many premade nootropic blends use it primarily for its unparalleled benefits of natural memory-booster.

However, studies have shown Bacopa seems to prevent the rise of anxiety in aging but is more of a modulator that doesn’t act overly powerful. Another study showed significantly reduced anxiety and depression scores in adults, compared with the placebo. An antidepressant and stress effects were also observed, but in a relatively small size.

22. Ginkgo Biloba

picture of a leaf of Ginkgo BilobaWhile this herb has no effect on depression or other mood disorders, one high-quality clinical trial showed that a higher dose (up to 480 milligrams) of Ginkgo Biloba reduced generalized anxiety symptoms by the end of four weeks. The researchers found that the maximum daily dose was more effective manually and that the reduction in symptoms did not gain statistical significance until after a full four weeks had passed.

23. Uridine

Uridine is an important nootropic that plays a big role in brain and cognitive function. It is a component of Ribonucleic Acid (RNA) that helps your DNA to create a memory by making strong connections between brain neurons.

Uridine modulates and stabilizes dopamine release and helps create new dopamine receptors by activating the D1 and D2 receptor signaling cascade. This will improve your mood and motivation by reducing stress.

It is promising in treating depressed adolescents with bipolar disorder, although the new studies should confirm that.

For fortifying mood, Uridine is especially good in combination with Alpha GPC. Like in the Beginner’s nootropic stack by Double Wood Supplements.

24. Magnesium

Magnesium is an essential mineral in the diet and the second most common electrolyte in the human body. Scientific research has shown that people who suffer from depression often have a magnesium deficiency and that this increases the risk of developing depression.

After oral magnesium supplementation, reduced depressive symptoms have been found in elderly diabetics.

Magnesium supplementation for several weeks has been found to have a positive effect on symptoms of depression and feelings of fear. Magnesium shows a comparative antidepressant effect and is a meaningful adjunctive therapy in depression.

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25. Vitamin B6 & B12

Also known as pyridoxine, vitamin B6 affects many physical and mental functions. In addition to strengthening the nerves, this vitamin fights depression, especially that caused by hormones.

Research has shown that vitamin B12 affects our mood, i.e. depression. Namely, studies have proven its balancing effect. It increases energy, shortens sleep time, improves the quality of sleep and wakefulness during the day.

26. Sulbutiamine

Sulbutiamine is a synthetic molecule developed by Japanese researchers in the 60s to treat thiamine (Vitamin B1) deficiency. So, it’s an upgraded version of vitamin B1 because it consists of its two fused molecules. This nootropic is fat-soluble, rapidly absorbed, and crosses the blood-brain barrier easily. 

Sulbutiamine’s primary effects are to reduce mental and physical fatigue and to boost energy. These two functions will also improve your mood. As vitamin B1 is the only vitamin used in the synthesis of acetylcholine, Sulbutiamine may also boost long-term memory.

Few human studies show that Sulbutiamine has no antidepressant effect but can accelerate the recovery of depressed patients by facilitating their rehabilitation in social, professional, and family life.


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The nootropic community takes it in doses of 200-600 mg, best in the morning, on days when you feel sluggish and out of focus. When used in normal doses of 200-1000 mg, Sulbutiamine is safe. Otherwise, in higher doses, people report anxiety and negative thoughts.

27. Phenibut

graphic of cosmonaut sitting on the moonPhenibut is a GABA-mimetic psychotropic drug developed in the USSR in the 1960s that was used in a Soviet cosmonaut program. Phenibut possesses both calming effects and improves cognitive capabilities. It has a similar structure to the GABA neurotransmitter, and mood-boosting activity has been shown to correlate with Phenibut’s affinity to bind to GABA-B receptors.

Along with its racemic form that is used clinically, there are two commercially available isomers of the substance, R-phenibut, and S-phenibut. It has been investigated that the version of R-phenibut is better for mood-boosting effects.

The recommended dose of Phenibut for anxiety is 250-500 mg, which you can take three times a day. Russia boasts the best Phenibut preparations, where, unlike the US, 250 mg in one tablet is the standard for mood treatment.

Read our Cosmic Nootropics review for more on the original pharmaceutical-grade Russian Nootropics.

28. Aniracetam

Aniracetam is one of the original racetam drugs developed by Dr. Corneliu Giurgea, who coined the term nootropic. It is considered an anxiolytic (anxiety-relieving) and one of the most effective mood support compounds that the nootropic community likes to use.

It seems to interact between the serotonergic, dopaminergic, and cholinergic systems according to the research.

It also appears to have some GABAergic effects that can improve mood and alleviate nervousness without sedation that further impairs cognition.

29. Fasoracetam

Fasoracetam is a new member of the racetam family of nootropics. It appears to interact and modulate three major neurochemical systems in the brain. To improve memory, it acts on acetylcholine, and to improve mood, it establishes an optimal balance of excitation and inhibition in the neural circuits of GABA and glutamate.

Although there are no clinical trials in humans to confirm the claims, studies in rodents are encouraging. It is to be believed that Fasoracetam is as safe as other racetams.

30. Noopept

Noopept is a peptide nootropic related to the racetams. It is far more potent than the other traditional racetams and is taken in much smaller doses (10-40 mg is a recommended daily dosage).

Noopept is a popular psychostimulant that stimulates the brain without increasing heart rate or direct stimulation of the body. Anecdotal use is widespread and suggests that Noopept can alleviate anxiety, improve confidence, and elevate mood.

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31. Modafinil

Modafinil is a prescription drug for Narcolepsy that is also an incredible mood enhancer. Subjective well-being and enjoyment during cognitive tasks appear to be significantly improved by modafinil supplementation.

The primary mechanism that makes modafinil one of the most powerful mood enhancers is dopamine stimulation. Although studies suggest modafinil doesn’t have strong enough properties to induce euphoria and addiction, it will improve most people’s mood through dopamine alone.

32. Picamilon

Picamilon is a nootropic synthesized in the USSR for ordinary people. The main mechanism is to improve cognitive functions and increase mental energy, while reducing feelings of stress and anxiety.

Its effects are similar to those of Phenibut as both drugs reduce anxiety and improve mood. However, unlike Phenibut, Picamilon has a much stronger impact on brain energetics because it stimulates the consumption of oxygen and glucose by the neuronal tissue.

Mood enhancers tips

Mood and gut health (probiotics and prebiotics)

While Hippocrates has famously said that “all diseases begin in the gut,” only recently has more extensive research begun on the link between brain health and gut health. And how those two communicate through neural, endocrine, and immune pathways. 

While still in the infant stage, novel studies say that gut microflora is linked to psychological health. A microbiome is a community of ‘good’ bacteria that is important for our immune system and digestion. Our gut is also responsible for producing a good deal of the body’s serotonin, which is a mood support chemical.

If lacking good bacteria in the digestive system, you may be prone to suffer from depression, anxiety, and insomnia. Clinicians found that the types of macrobiotic strains in depressive patients’ guts are different from in healthy people.

Studies show that probiotics in combination with prebiotics can alleviate the symptoms of depression. Also, the symptoms of anxiety become less pronounced and people who have taken probiotic supplements become more resistant to stress. One study, in particular, showed that probiotics can affect cognitive mechanisms that are known to determine vulnerability to mood disorders.

While it is important to add food rich in probiotics, it is also beneficial to add supplements to a diet.

Mood probiotics Amazon
Mood probiotics Amazon

Mr. Happy Stack - mood, focus, and energy

Probably a better option than taking a single nootropic for mood is taking them in the popular stacks of two or more nootropics. Stacking nootropics is valuable if you want to reap the benefits of their synergistic qualities. They mix well and amplify individual effects with each other, which can unleash the true power of different benefits.

One of the most popular combinations of nootropics to support mood, focus, and energy is the so-called Mr. Happy Stack.

The origin of this popular stack is on the Longecity forum when the thread was launched by user “Mr. Happy” and explained how this combination of nootropics affects him.

This stack consists of Uridine, CDP-Choline, and Fish Oil as a basis, along with B6, B9, B12 vitamins, and selenium.

Some premade nootropics manufacturers are also producing their own version of Mr. Happy stack.

What life hacks lift your mood instantly?

You can do a lot of things naturally, which will lift your mood and be a cornerstone for better psychological health.

While we are a website that reviews the best cognitive supplements, these common-sense things will help make them not your only choice.

Nootropics work best when you’re healthy, and mood enhancers will be much more effective if you adopt some of these recommendations.

  1. Get up early and go for a morning walk. Be in the fresh air and sunshine whenever you can. It’s a known fact that vitamin D (the “sunlight” vitamin) can influence serotonin synthesis. This will improve your mood and self-esteem to start a productive day. 
  2. What you eat affects how you feel. Focus on eating whole foods to not feel bloated and sluggish.
  3. Beautify and tidy up your living space. Throw out the excess.
  4. Meditation and gratitude naturally boost your mood and improve mental health. 
  5. Exercise releases endorphins into our bodies to make us feel good. You can improve your mood immensely by regularly breaking a sweat.
  6. Socialize, don’t isolate. Reach out to an upbeat friend. 
  7. Listening to music can greatly improve your mood.
  8. Gardening or working in the yard is great as the color in our surroundings also affects our mood.
  9. Create something and be creative in your hobbies! 


A bad mood or a depressed state has an extremely negative effect on someone’s cognition.

It is similar to anxiety and the consequences of stress that can numb one’s level of thinking and cause a person to squander the potential of their mind.

To counteract, research all of these nootropics for mood support and find a balance in responsible use.

If DIY, add three of these supplements to start your daily regime. Otherwise, the effects will be subtle.

You might even want to try the best pre-made stacks that also use nootropics to support mood. If you are looking for it, read the following post.

Pick up nootropics that best reflect your goal

Read our next article to get you started

Best nootropic stacks

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