The 6 Best Nootropic Stacks To Enhance Performance


It’s reasonable to try a single ingredient before you learn enough to DIY nootropics stacking. But, many people are not inclined to do that.

The simplest method is to take a ready-made nootropic stack that fits into a capsule.

A premade nootropic stacks save time to your supplements regime, reduce the side effects of ingredients and save money to neurohackers.

Knowing stacks you will sharpen your ability in finding the ideal nootropic combinations that will raise performance to another level.

Some things matters when recommending stacks:

  • If you are at the beginning and want to try how combinations feels

  • If you don’t want all that weird gadgetry – part of the DIY process

  • If you want to take efficient nootropics when you are at a go or at work

Let’s start with our list of the 6 best pre-made stacks, followed by nootropic stack guide.

Table of Contents

Best premade nootropic stacks

6 best nootropic stacks
Brands Manufacturers Rating

Wolfson Berg Limited

Natural Stacks

Opti-Nutra LTD

Nootripure Laboratories

Neurohacker Collective

Opti-Nutra LTD

NooCube nootropic stack for mental speed and reduced stress

Picture of NooCube bottles for best nootropic stack review

“There are over 124,000 smarter people in the world today thanks to NooCube.”

– NooCube

The appeal for the NooCube dietary supplement in the first three years of quick business development reveals the increasing demand for the most popular natural nootropics. As well as the increase in the term ‘smart drugs’.

The team of neuroscientists, navigated by this pattern, put together the most investigated and medically backed natural ingredients to a synergistic blend that helps and improves your focus, mental speed, and memory.

Nootropic ingredients in NooCube noticeably increase brain function and your body efficiency become in general better. Because it’s made to be safe, NooCube is not overly stimulative however rather a mild supporting supplement with beautiful all day lasting effects.

The absence of caffeine and other energy fillers does that NooCube operates on natural mental power as a substitute for coffee feels. This makes it a good beginner nootropic stack.

The manufacturer made all transparent and backed the project by several research studies, substantial research, and years of scientific trials of ingredients.

label of the ingredients in the 'NooCube' formulation
NooCube list of ingredients

What makes NooCube special?

NooCube improves memory and cognition by enhancing the production of several essential neurotransmitters in the brain. 

Especially acetylcholine, one of the most exemplary neurotransmitters that play an essential role in storing and recalling memories, focus, learning, as well as information retention, and muscle motor function. 

  • Boosts neurotransmitters for better mental speed

  • Encourages the growth of new neurons and repairs damaged

  • Strengthening the brain synapses

  • Antioxidant properties

With more acetylcholine in the brain, all mental processes are taking place more speedily and efficiently. 

The key ingredients include:

Bacopa Monnieri – Accelerates mental processing, optimize cognition under stress and promote relaxation.

Huperzine-A and Alpha GPC – boost acetylcholine for better mental processes. 

L-theanine – improving wakefulness and relaxing state

L-tyrosine and Out straw – Enhance mental performance under stressful conditions

Cat’s Claw – neuroprotection


NooCube benefits

After taking NooCube the state of mind gradually becomes better, the attention to details being finer and the ability to complete tasks imminently.

  • Memory

  • Reduces stress

  • Improves concentration

  • Mood booster

  • Supports creativity

  • Increases libido

This tool is great when you have to be focused for a longer period without distractions. Memory gradually becomes better due to a well-dosage of Bacopa.

Like in most all nootropic supplements, the benefits from NooCube will be present as long as you persistently take it. It’s non-addictive so as soon as you stop the effects will last for a while, and you’ll gradually get back to your more natural function. But with some long-lasting-memory benefits.

NooCube is trying to be a complete brain upgrade but seems to be a little under-dosed for that purpose. This may indicate differences in outcomes for some users and inconsistencies daily due to tolerance problems. For other users from all age groups, it seems to be no problem.


Who are Noocube users?

NooCube is popular among a different range of productive people from all age groups. College students that seeking an extra boost to get them through their studies, as well as professionals pursuing the edge in the high-pressure corporate world, public speakers.

This stack doesn’t disrupt your natural state of mind, so it’s a quite safe recommendation for nootropic beginners. I’d like to call it the gatekeeper.

I still like to take it occasionally because I like the feel of these specific ingredients. For some reason, I like what it’s doing for my empathy side.

People that have been utilizing Alpha Brain, the first mainstream pre-made stack, actually state they are practically similar in feel. Yet NooCube is a cheaper variation of ingredients and a more transparent one.

Suggested dosage: 2 capsules with meals or fatty acids. You can go up to 4 capsules daily.

Read in-depth NooCube review



NEUROFUEL (CILTEP) nootropic stack for memory and focus

Picture of NEUROFUEL bottle and caps for best nootropic stack review

Better brain better life. Use NEUROFUEL to remain sharply motivated and focused for hours.”

– Natural Stacks

Almost ten years after the accidental discovery of a member of the Longecity forum, the popular CILTEP (sil-tep) stack continues to impress with its ingenious formulation. Now under the new brand NEUROFUEL, it is one of the longest-lived nootropic records and is distributed by Natural Stacks. They called themselves the world’s first open-source supplement company, proud of the transparency of their supplements.

This 100% natural stack has all the advantages from the competition despite its apparent simplicity. It heightens your level of concentration, focus, and memory function both short and long-term.

CILTEP is actually an acronym for “chemically-induced long-term potentiation”. Long-term potentiation (LTP) is a biological system behind the brain’s ability to form and store new knowledge and behavior, memories, and learning that can last up to a lifetime.

The idea behind CILTEP (NEUROFUEL) is still highly theoretical as well as anecdotal since it’s essentially an oversimplification of exceptionally complex cellular mechanisms into elementary math. Yet the hype is born since the product is working and users from around the world are liking it. 

CILTEP list of ingredients

What makes NEUROFUEL special?

NEUROFUEL is a combination of three pharmacological classes of chemicals rather than stacking ‘the most potent nootropic ingredients’ together to see what is their synergistic effect. 

  • Nutraceutical composition for PDE4 inhibition

  • Enhanced dopamine metabolism

  • Long term potentiation (LTP)

Theory behind CILTEP is that artichoke extract is a good source of luteolin. Luteolin is a PDE4 inhibitor and can thus raise cAMP levels. Forskolin increases cAMP levels by inhibiting its demise. And you can combine the two and create a significant elevation in cAMP levels and subsequent facilitation of LTP mediated by CREB, like you would get from a potent PDE4 inhibitor (rolipram).

Stacking ingredients in this way directly stimulate the biochemical machinery that underlies synaptic plasticity.

Benefits of NEUROFUEL

NEUROFUEL stops the brain fog all of us have at those moments when it’s impossible to remain focused. As a little surprise, these five active ingredients bring a very sharp focus! This is due to the well-distributed dose of each ingredient.

The boosting in the activity of other essential neurotransmitters such as acetylcholine, dopamine, and epinephrine will certainly benefit the rising in cognitive capacities along with a general speed rate.

Due to that activity as well as that it improves the level of sensitivity to numerous hormones as well as natural chemicals, people also utilize NEUROFUEL to naturally enhance athletic performances.

  • Increase motivation

  • Optimize mental energy

  • Provide strong concentration capacity

  • Preserve long – term memory recall

  • Stabilize mood and social skills


Who are the NEUROFUEL users?

NEUROFUEL (CILTEP) is branded like a study aid, but it’s really made for adults working hard. It can improve mental focus in your daily life, whether you need it at work, in the house, or at school.

Most users of NEUROFUEL experienced an increase in their desire to study, as well as in the absorption of information. Students, scientists, doctors, business executives, filmmakers, firemen, and lots of others are reported the efficient usage from enhancing awareness and endurance, to having an additional sharp focus as well as memory increase.

Suggested dosage: 1-3 capsules per day, in the morning on an empty stomach.

Read in-depth CILTEP review



Performance Lab Mind nootropic stack for stim-free energy and brain health

Picture of Performance Lab Mind bottles for best nootropic stack review

“The only nootropic that enhances cognition and helps your brain recover from intense mental exertion

– Performance Lab

Performance Lab is a U.K.-based supplements company owned by Opti Nutra Advanced Nutraceuticals. They produce all their supplements in the USA.  This is just part of the reason why the company literally has every certification you can get as a supplement maker. That makes them distinct amongst online competitors.

You’ll hardly find a supplement manufacturer that uses as many testing methodologies as Opti-Nutra. Their nutraceutical supplements provide support in wide areas of health benefits including sleep, vision, cognition, energy, and workout.

The one in front of you is the cognition-enhancing nootropic (Mind). Performance Lab Mind is a four-ingredient blend that contains a mix of essential brain supplements in synergy with one another.

Lab Mind is designed to fight off stress burnout all while supporting brain health in time.

The key components are the best bioavailable forms and trademarked nootropics that you can stack together. This nootropic stack boosts brain energy and reduces mental tiredness by supporting mitochondria and boosting cerebral blood circulation.

The key active ingredients include many characteristics:

Cognizin®Citicoline boosts brain energy by 13.6%, build brain cells and optimize brain cell functions. It supports learning, attention, and memory. Optimize the mitochondria, support cerebral blood flow, and stabilize brain cell membranes.

Sharp-PS® Green eco-friendly Phosphatidylserine – promotes Nerve Growth Factor (NGF). Also, serve in the brain regeneration phases, Neurogenesis, Neuroplasticity, and Neural repair.  PS also optimizes brain cell membranes for peak performance.

Maritime Pine Bark Extract (95% proanthocyanidins) – supply antioxidants that cross the blood-brain barrier to fight off free radicals. Optimize brain plasticity and brain cell regeneration. Relaxes blood vessels for delivery of micronutrients in the brain.

Ajipure® L-Tyrosine – raw material for synthesis of performance-oriented brain chemicals like epinephrine, norepinephrine, and dopamine. Fight off stress by preserving norepinephrine. Green technology that turns non-GMO and gluten-free vegetable-derived carbs into bioavailable amino acids.

With just 4 main ingredients this cool supplement has all that it requires working on numerous brain pathways at once. Since it’s a smart stack, you’ll feel the outcomes. Although, you will need to give it some time before you start noticing improvements.

List of 'Performance Lab Pro' ingredients label
Performance Lab Mind label

What makes Performance Lab Mind special?

PLM also contains a secret ingredient in the form of a prebiotic capsule. It is 100% natural prebiotic-infused NutriCaps® made from pullulan (fermented tapioca). It’s safer to use it that way, and it’s vegan-friendly. NutriCaps® disintegrates right away once you take it. So, it’s a costly way for the manufacturer to provide end quality, but as we said – take the best forms of every supplement.

What is special about PLM is that it stacks great with other product categories from the company list. Like with its predecessor Performance Lab® Whole-Food Multi, multivitamin required for the overall health of men and women. And with a source of dietary fat such as Performance Lab® MCT. Or, Performance Lab® Stim, balanced caffeine stimulation.

This makes PLM an ideal nootropic stack from our list for the custom stacking.

To summarize with a few facts promoted by their customers:

  • ”Industry-Leading Ingredient Blend”

  • ”The Quality is in the Details”

  • ”Performance Lab® Mind is Good Value”

A few of these subtleties make Performance Lab Mind the first pure nootropic on our list so far. It has all the right ingredients and a strategy of how brain supplements should be made.

A great example from the nootropics stacking strategy. That way you can make your own self-formulated stack.

Performance Lab Mind benefits

Performance Lab Mind promotes peak, psychological performance in high-pressure environments. Normally the best nootropics offer you loads of stim-free mental energy. This one is devoid of caffeine, so you will only feel the clean natural stimulation.

Neurohackers also talk about a boost in these categories:

  • Focus

  • Better reaction-time

  • Brain processing speed and memory

  • More brain energy, less brain fog

  • Mood improves

  • Balance hormones depleted by stress

  • Lowers cortisol

Rather an impressive list of biohacking goals for just 4 ingredients stack. So long if you don’t expect it to act like the nootropic blend with way more ingredients.

Performance Lab Mind users

Performance Lab Mind promotes peak mental performance in high-pressure environments, one you should value if you are a core working professional. It goes without saying that it will be good for the elderly. But it’s also good for anyone who wants to perform in the best light under stressful conditions. 

This supplement has revolutionized healthy performance nutrition through the use of branded ingredients, advanced nutritional technologies. Also, with the plant-based, eco-friendly approach. There is no need to look beyond the basics if this is what you’ve been looking for.

Suggested dosage: Opti Nutra recommends taking 1-2 capsules of Performance Lab Mind in the morning or early afternoon.



THRIIV nootropic stack for mental clarity, enhanced recall, reduced stress, and productivity

Picture of THRIIV package for best nootropic stack review

“The most effective cognitive enhancement product in the world.

– Nootripure Laboratories

THRIIV by Nootripure Laboratories is a newcomer though it’s already making a strong impression at the premarket. This is a quick-acting 12-hour boost of energy formula. Designed for creativity, confidence, and concentration to max your productivity. In our opinion after beta testing, it is a good example of how the stacks should be made. 

This stack is created by a team of scientists and medical experts from diversified backgrounds (Ayurvedic, Chinese). THRIIV is a powerful nootropic made with a mix of herbs, extracts, neuro-vitamins, and other nootropic compounds that don’t look shallow at all.

Nootripure’s team has put great value into its premium supplements. As well as excellent education and program for health goals. In their own words, for the most effective cognitive enhancement in the world.

Nootripure has made an effort to customize its inventory across the entire line of premium products. Now it covers every possible nootropic target that might interest you.

  • Peak athletic performance

  • Enhanced productivity

  • Rejuvenating sleep

  • Enhanced love

  • Long-term brain-care

THRIIV is an interesting nootropic stack primarily for energy and focus. But, also for peak cognitive performance. Very cool mix of natural and synthetic compounds for enhanced productivity. Works pretty safe, too. 

THRIIV list of ingredients

What makes THRIIV special?

Although you can purchase a very good ‘energy supplement’ mix of natural and synthetic nootropics, none of them have actually patented CBD products. 

Nootriplex is a unique cannabinoid formula developed by Nootripure Research Foundation. It uplifts cognitive functions and offers a happy and pleasant vibe. Nootripure uses it in all of its pre-made stacks.

NewCaff ™ is a recent innovation that uses nanoparticle technology that allows the absorption of caffeine at a steady rate without disturbing the physiological balance of your body.

Each of the 15 ingredients in THRIIV is top-notch. 

  • Increase acetylcholine levels in the brain

  • Powerful adaptogen mix of herbs 

  • Neuroprotective agents shield 

  • Cannabinoids for relaxing, focusing, healing, and anti-anxiety effects

THRIIV has long-lasting benefits with no adverse effects to bother with. In our opinion, it is a pretty potent nootropic that will be respected among biohackers.

THRIIV benefits

THRIIV generates a powerful nootropic effect, a combination of calming energy and mental strength. Which helps to get things done quickly. You’ll have the benefit of shortening your understanding process and just being in the zone of productivity.

The dose costs less than standard coffee, but it pays off, without the rush or jittery that coffee sometimes gives. 

  • No crush like in cheaper energy supplements

  • First-class focus

  • Mental clarity

  • Verbal fluency

  • Confidence

  • Better memory

  • Balanced energy

  • Creativity 

I had the ability to reduce the execution time of my projects, both visual and written. As a pre workout supplement THRIIV got me a special dimension in body’s performance.

Who are the THRIIV users?

It’s a great tool for peak athletic performance because it has the right ingredients for active sport. But it’s also good for students, business owners, service technicians, public speakers, employees from innovative careers, shift workers, or anyone who wants to perform at their best. 

If you are +55 and have related problems with declining in performance, THRIIV may be a good supplement to try.

Suggested dosage: take a maximum of 2 capsules a day with a meal. To avoid desensitization of effect THRIIV should be cycled.

Read in-depth THRIIV review



Qualia Mind nootropic stack for enhanced focus, memory, and mental clarity

Picture of Qualia Mind bottle for best nootropic stack review

Imagine more. Dream bigger. Go make it happen.

– Neurohacker Collective

Specifically designed to promote focus, support energy, mental clarity, working memory and mood regulation – Qualia Mind is a superior supplement compared to other nootropic brands in the marketplace.

The premium quality of this product reflects the management team at Neurohacker Collective that is credited for some revolutionary ideas and thinking outside the box.

Created by diverse thinkers along with scientists and doctors from Stanford University and others, Qualia Mind transcends the usual principles of brain supplements. The whole Qualia Mind cognitive upgrade in capsule focuses on the objective to aid the future of humankind.

Its reputation of being one of the strongest nootropic stack is indisputable. It tackles multiple goals at once and works from the start to bring you the present results as well as lasting benefits.

list of the ingredients in the Qualia Mind supplement
Qualia Mind list of ingredients

What makes Qualia Mind special?

Qualia Mind is an ultimate nootropic stack of 28 vegan-friendly ingredients that fall into different classes of compounds that make this stack unusually advanced and rarely seen among top-notch supplements. 

It consists of:

  • 7 neuro-vitamins

  • 6 adaptogen extracts

  • 5 amino acids

  • 2 choline donors

  • 2 antioxidants

The final product possesses the purest, potent, and bioavailable form of each well-dosed active ingredient. The manufacturer claims that every ingredient used is the result of their whole design methodology. 

Special care is taken to understand how those ingredients combine and are based only on strong empirical research.

Because of so many of the ingredients that tend to bring results to most people, it’s also a riskier way to get some stomach complications. But it looks like a great job is done by the company to meet all safety requirements. With no serious complaints or negative reviews in the community. Au contraire!

For those sensitive to caffeine, Qualia Mind caffeine-free is a great addition to the Neurohacker product line.

Benefits of Qualia Mind

The biohackers that take Qualia Mind rapport a very smooth experience with some interesting outcomes. 

  • Increased mental clarity / lucidity

  • Enhanced ability to enter a flow state

  • More energy and productivity

  • Decreased procrastination

  • Increased focus and concentration

  • Mood-uplifting effects

  • Increased creativity and generating ideas

  • Increases linguistic and mental sharpness

Benefits can be felt in as soon as 40 minutes, delivering calm energized focus all day. Keep in mind that Qualia is not overly stimulating, so you will not become something you are not. It will remove distractions and expand your cognitive potential as well as increase your mental reactions. 

Who are the users of Qualia Mind?

Qualia Mind already has many advocates among well-known doctors, fitness trainers, nutritionists, as well as ordinary people in search of an all-in-one solution.

As the aim of Qualia Mind is to bring optimal performance for everyone, the users are people from different backgrounds, ages, and life orientations. 

Obviously, though, it is a fairly expensive product and slightly inconvenient to use as you have to take at least 7 capsules per day.

But for the promises it can bring this might not be the main obstacle.

Suggested dosage: Up to 7 capsules per day. The optimal dosage of Qualia may vary based on your chemistry. Start with the 5 capsules. To avoid desensitization of effect, Qualia Mind should be cycled. We recommend taking 2 days off each week.

Read in-depth Qualia Mind review



Mind Lab Pro® nootropic stack for cognitive improvements in all aspects

Picture of Mind Lab Pro bottle and caps for best nootropic stack review

100% brain power. 

– Opti-nutra LTD

While you’re haunting the phrase “best pre made nootropic stacks” on Google or anywhere else, you’ll see this supplement in many recommendations.

Mind Lab Pro® is a sister company of earlier mentioned Performance Lab Pro®. The owner is the same manufacturer Opti Nutra Advanced Nutraceutical. 

This nootropic stack is an advanced version of Performance Lab Mind. Instead of four, it has eleven ingredients. Among the best pre-made nootropic stacks, Mind Lab Pro is a classic example of how to make a good pre-made stack. Especially, with goals in mind to optimize memory, mental performance, mood and stress resistance, maintenance, and brain repair.

This all-natural stack is a classic ”nutraceutical” and nootropic to discover.

Mind Lab Pro® is still the golden industry standard when considering pre-made stacks. Even today, when new stacks tend to be more advantageous.

Opti-Nutra created this stack to target and unlock the potential of every area of your brain, not just a few brain pathways as most companies presented in their blends.

Mind Lab Pro® is completely in natural mode. Even the capsules are plant-based, not a semi-synthetic polymer used by others. The packaging is also recycled and biodegradable.

Mind Lab Pro list of ingredients

What makes Mind Lab Pro special?

The fact that you know you are getting full-spectrum nootropic ingredients is the main benefit of this stack.

Read in our previous post about the power of standardized natural extracts, and how to get the best out of nootropic ingredients.

To name a few of the great extracts you’ll find in MLP:

  • Citicoline (Cognizin®) – is called a ‘multitasking nootropic’ as it affects many brain pathways like brain energy, neurotransmitters, brain blood flow, brain waves, neuroprotective, and regeneration. Cognizin is an extremely pure, branded, standardized form of Citicoline.

  • Phosphatidylserine (Sharp PS® Green) PS increases Nerve Growth Factor (NGF) levels which helps promote neurogenesis, maintenance, and repair. PS also helps immune cells. The Sharp PS® Green extract is from sunflower lecithin.
  • Bacopa Monnieri The main star in the world of neurotransmitters support, brain energy, cerebral circulation, and neuroprotective. Bacopa offers all of that. Mind Lab Pro uses a specialized extract with the precise dosage of nine active nootropic compounds: Bacosine, Bacoside – A, Bacoside – I, Bacoside – II, Bacopasaponin C, Apigenin, Luteolin, Beta-sitosterol-D-glucoside, Jujubogenin isomer of Bacopasaponin C.

  • Lion’s Mane Mushroom – improve brain function across many parameters. It regenerates neurons and fights nerve damage. It stimulates enzyme production that releases Nerve Growth Factor (NGF). With the whole fruiting body extract, it has deep and long-lasting effects.

  • Maritime Pine Bark Extract – MLP is the first pre-made stack that started using this great ingredient. It’s a vasodilator that improves the blood flow in the brain. And promote Brain-Derived Neurotrophic Factor (BDNF), an important protein for brain regeneration.

In the perfect synergy of the ingredients, where each ingredient tackles a few brain pathways and form strong connections throughout this stack, it’s clear that MLP will have strong benefits.

Benefits of Mind Lab Pro®

Can you really expect 100% brainpower? 

Well, if you ask the experts, Mind Lab Pro can even be compared to synthetic solutions like Racetams or stimulants like Modafinil. Although Mind Lab Pro doesn’t have the same intensity, it’s still better than these for long-term health. The secret lies in the fact that the synergy of the correct forms of natural nootropics can be so strong.

Anyway, I would not compare it to the mentioned substances. People so often compare different classes of supplements, which is wrong because no size fits all. All of them have their pros and cons. 

Although Mind Lab Pro is not the strongest solution in the marketplace, the benefits/goals it presents are achievable for beginners and experienced nootropic fans.

  • Better short- and long-term memory

  • The Alertness, concentration, focus, motivation

  • Decision-making is faster and better

  • Dramatically reduced anxiety levels

  • Better mood and quality of life

Mind Lab Pro is primarily a way to improve cognitive performance using well-studied and pure compounds that do not have a major risk of adverse effects. This definitely puts it in the class of the best nootropic stacks.

Who are the users of Mind Lab Pro®?

When you’re searching for the best nootropic stack for studying where attention, storage, and recall are substantial, Mind Lab Pro is often a choice of learners. 

For gym enthusiasts or serious athletes, it works on willpower, motivation, and intensity of training.

For competitors, it will work in the form of sharp thinking and a clear mind.

In a working environment where you must multitask under stressful conditions and be creative with problem-solving, it will boost performance.

For our elderly that seeking extra support, it could bring them back a memory, verbal communication, mood, and mental clarity.

Suggested dosage: two capsules with meals last the entire day.

Read in-depth Mind Lab Pro review



nootropic stack meaning

A nootropic stack comes in a combination of two or more ingredients taken together or in a sequence of mini-stacks that will create specific cognitive effects.

Basically, there are only two methods for stacking nootropics:

  • Self-formulated nootropic stack

DIY method that allows you to experiment with individual nootropics, dosages, and components of the stack. It is a favored option of stacking for veteran users. Read more about it in our guide for stacking nootropics.

  • Pre-made nootropic stack

The companies that pre-formulated stacks provide solutions especially good for beginners and of course for our elderly. A pre-made nootropic stack gets you the convenience of an all-in-one dosage with proven stack results. They include nootropics benefits which you won’t find in solo nootropic supplements. Using this solution, you are also not exposed to as many possible side effects as when weighing and mixing your own nootropic stacks. Some nootropic vendors even sell the custom premade stacks for memory, focus, energy, etc. You can combine them together to your own preferences.

These methods will manifest the results more speedily and notably than using individual nootropics which are often mild in effect. 

Best nootropic stacks benefits

Stacking nootropics alone does not necessarily mean that they will produce the desired result.

And not all companies want you to know that.

The good companies are careful in the stacks making by combining nootropics to improve absorption, increase potency, amplify the benefits, or reduce the side effects of their formulations.

Just as cognition arises from the coordinated activity and the complex balance of multiple elements, so all of these elements should be optimized for the ultimate and long-term cognitive enhancement.

Therefore, targeting pathways is more likely to be more useful than targeting a single chemical reaction like producing acetylcholine for memory and learning.

Or adding caffeine as the main energy ingredient to cheat that supplement is working.

To increase the efficacy of the pre-made nootropic stacks manufacturers work on these:

Target specific cognitive issues

The goal should always be to create a nootropic stack which properties amplify a particular cognitive effect.

And then another effect.

The experienced biohackers recommend taking a stack of at least 4 to 5 targeted nootropics to resolve each of your biohacking goals.

This is how companies design stacks for particular target outcome(s).

  • Memory and learning
  • Focus and Concentration
  • Longevity and healthspan
  • Creativity
  • ADHD
  • Mental clarity
  • Sociability
  • Mental/chronic fatigue
  • Motivation
  • Stress

What is the best nootropic for motivation?

Energy and motivation go hand-in-hand. Dopamine is critical for motivation and there are many potent nootropics that take care for a dopamine system. To name just a few that will raise your energy levels: L-tyrosine, Rhodiola Rosea, Resveratrol, Citicoline, Mucuna pruriens, Lion’s Mane Mushroom, B vitamins.

Which nootropic is best for studying?

Some common nootropics are very good to help us improve memory, focus, and concentration. They are a fantastic aid for students and learners of all kind: Caffeine + L-theanine, Bacopa Monnieri, CDP-Choline (Citicoline), Acetyl-L-Carnitine (ALCAR), Ginkgo, Phosphatidylserine, Rhodiola Rosea.

What is the best nootropic for anxiety?

There are many things from our personal lives as well as our work pressures that can cause anxiety. Fortunately, there are also many natural nootropics that have been shown to be effective in relieving stress and even more severe mood and anxiety disorders. To name a few: Bacopa, L-theanine, Rhodiola Rosea, Gotu Kola, 5-HTP, Valerian Root, Ashwagandha, Kava Kava, Vitamins B6, B9, and B12.

Best nootropics for ADHD?

Attention deficit disorder is a condition associated with impaired executive function, attention, and working memory within the brain. Good ingredients to counteract ADHD would be Caffeine, Ginkgo, L-theanine, L-tyrosine, Omega-3 Fatty Acids, Ashwagandha

Best nootropic for focus?

Using nootropics for focus and concentration issues has become one of the most prominent reasons people have turned to nootropics in the first place. Some good ones are Panax Ginseng, Ginkgo Biloba, L-Tyrosine, CoQ10, caffeine, Huperzine-A, Zembrin® Kanna extract.

Increase nootropic synergy and potency of ingredients

The best pre-made nootropic stack contains ingredients that boost each other and polish off the “rough edges” of each involved nootropic while sustaining their cognitive benefits.

A classic example is the pair of L-theanine and caffeine, two cognitive enhancers most commonly found in nootropic stacks. L-Theanine helps alleviate the harmful effects of caffeine but can reduce its energizing effect.

Then Bacopa Monnieri and CDP choline popular duo as ultimate memory compounds. This combination not only can improve acetylcholine levels but keeps them longer active for improved memory and learning capacity.

N-Acetyl-L-Tyrosine and B Vitamins synergy is often put into the stacks for motivation goals by producing and replenishing catecholamine neurotransmitters.

Improve absorption of the solo ingredients

To achieve the best possible pharmacodynamic profile or the output of their nootropic stack, the manufacturers need to optimize the pharmacokinetics of bioactive compounds.

The absorption of the ingredients of the stack is eventually what will bring you the benefits. 

For example, Piperine with Curcumin can improve its absorption and slow down the metabolism. This allows us to experience the greater effectiveness of curcumin.

Some stacks like Qualia Mind from Neurohacker has introduced even 28 nootropics to work on the whole system.

Mitigate side effects of ingredients

It is not always the case the most potent pre-made nootropic stack or the one with more ingredients will be your choice. Using a minimum number of nootropics in one stack also helps companies to keep costs low, minimizes the risk of adverse effects, and allows them to track each ingredient to make adjustments accordingly.

How to choose nootropic stack?

On our website, we are generally aware of three things when looking for the best pre-made nootropic stack.

  • When it comes to cognitive performance, it’s hard to say whether the supplement “works”.  

  • How well is the stack prepared is the second factor.

  • How well does it fit your goals?

So you need to do some preliminary research for yourself. When you know your goals, you’ll avoid pre-made stacks that maybe include something you don’t need. 

Here is some general guidance:

1. Avoid companies that source proprietary blends

The intent here is to hide the “proprietary secrets” of the formula by concealing the dosage of the ingredients. These players don’t want everything to be transparent and don’t provide exact ingredients and dosage. It’s not always a warning for scam products but anyhow. If proprietary blends include anything legitimate, the dosages are usually too low to be reliable.

2. BioAvailable Ingredient Forms in stacks

Some nootropic forms are designed for the best bioavailability. It is the ability of the compound to cross the blood-brain barrier (BBB) providing the higher potency. Many companies use the cheaper forms of nootropics and add them to their pre-made stacks. For the best bioavailability of your chosen nootropic stack look only for those companies that use standardized natural extracts, rather than plain powder herbal ingredients with no potency. 

3. Correct dosing

Sometimes the dosage can be too low to work or too high just to give the impression that the formula actually works. Any high-quality natural nootropic without additives will not show side effects in the correct dosage. Sometimes low-quality nootropic herbs can be grown under toxic conditions, creating a weaker end product. To compensate, a manufacturer may increase the dosage past the point of tolerability, and that can produce side effects. 

4. No fillers or additives

Whether this condition is met, see under “other ingredients” on the label. Additives, preservatives, fillers, synthetic compounds, and other questionable ingredients could lead to unwanted side effects like allergic reactions, mood issues, and upset stomach. Some of these harmful fillers are soy, silica, gluten, gelatin, palm oil, nuts, GMO ingredients, dairy, fish-based substances, artificial colors, and preservatives. If you find any of these, it’s probably a junk stack.

5. Try to use the sample of the stack 

Some manufacturers offer samples because they believe in their great product and know you’ll come back for more. This is good because you don’t have to start purchasing a bunch of things you know nothing about despite your research. You can try it for the price of shipping costs.

6. Medical advice

As a side note, you may also want to include visiting the medical specialist, doing blood tests, and even qEEG (Quantitative Electroencephalogram) brain mapping, to see where the exact deficiencies are in your neurology.

Is there a best nootropic stack on the market?

The answer is technically NO.

Once you spend long enough in the world of nootropics, it becomes obvious that this is a more nuanced question than might be expected. 

There is a lot of science and the research studies show the companies what to do to make a ready-made nootropic stack that works. The buyers always look between safe, effective and affordable solutions.

The ‘best nootropic stack’ is the one that is working for you, I mean, for your specific goals as well as for unique biology and brain chemistry.

Because each individual is biochemically unique, the optimum dosage and ingredients benefits and significance depend on your body weight and sensitivity. So what works for one person might not for another.

Picture of the man in front of the board looking for best nootropic stacks
How to find the best nootropic stack?


There is no one-size-fits-all nootropic stack.

The pre-made nootropic stack is usually good when these conditions are satisfied.

  • Good formulation strategy and message

  • Ingredients form & quality, formula, and transparency

  • Benefits and side effects of ingredients

  • User experience, trial, and money-back guarantee

  • Packaging

  • Honest reviews

  • Budget and value

We don’t think in advance that any of these stacks is ultimately the best one for you. These products are simply great brain tools that you can use to explore the potential of nootropics in your unique case. In all anecdotal and expert evidence, these pre-made blends give the best and safest cognitive results to neurohackers.

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