CBD Nootropics Benefits And Taboos You Should Break

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What is CBD oil? Taboos you should break

The insiders guide to CBD nootropics benefits

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Legality of CBD

What is CBD?

Cannabidiol was isolated from cannabis extracts by American chemist Roger Adams. However, no further investigation was carried out for almost 25 years, except for a few studies about its isolation. The exact chemical structure of CBD was elucidated only in 1963 by the group of Professor Raphael Mechoulam, from the Hebrew University of Jerusalem in Israel. Throughout the 1960s, the same group was responsible for the determination of the precise structure and stereochemistry of Δ9-THC and other major cannabinoids. These findings opened a new research field on the pharmacological activity of cannabis constituents. Before the 1970s, only a few pharmacological studies on CBD had been made, which concluded that CBD had no cannabis-like activity, as opposed to Δ9-THC (link).

brief history of cannabidiol

Cannabidiol can be drawn out from three sources:

  • marijuana

  • hemp

  • synthesized in the lab 

CBD is one of the 120 phytocannabinoids discovered in the cannabis species (Sativa and Indica). The cannabis plant has two key types, hemp (sativa) and also marijuana (indica). Both have CBD, yet there’s a much higher percentage in hemp, which additionally has very reduced (less than 0.3%) degrees of delta-9-tetrahydrocannabinol (THC) compared to marijuana. That’s why CBD from hemp won’t get you ‘high’.

Cannabis Sativa L. plant, a breed of hemp, is designed to minimise THC and maximise CBD, so that it consists of around 40% of the plant’s active substances. 

CBD Oil vs. Hemp seed Oil difference

CBD oil makes use of the whole plant, while hemp oil originates from its seeds. Cannabis CBD extracts primarily come from flowers and leaves of the marijuana plant. And from the flowers, leaves and stalks of the hemp plant.

  • Hemp seed oil is not CBD oil

When individuals speak about hemp oil, they’re referring to oil removed from the seeds of the hemp plant. There are no cannabinoids, CBD or THC, in hemp seed oil. Yet CBD oil is sometimes used to describe hemp seed oil, which consists of no active CBD. This component is loaded only with healthy fats and usually appears in beauty products for its hydrating benefits.

  • Hemp plant’s leaves and flowers are one resource of CBD oil

The term “hemp oil” frequently is made use of to refer to the CBD-rich product removed from the flowers and leaves of the hemp plant. Some full spectrum CBD oral drops use hemp seed oil as a carrier oil, as it is considered to be one of the most beneficial oils available.

Endocannabinoid System relationship with CBD

Although cannabinoids were first found in the cannabis plant, they in fact exist in a whole host of various other biological systems, including our own.

When the endocannabinoid system is first discovered in 1992, it is found to be important to human health and well-being through maintaining homeostasis (balance) in various aspects of physiology. In essence, homeostasis regulates all major body systems, ensuring they all work alongside one another.

ECS affects everything from learning and memory, mood and anxiety, drug addiction, appetite, inflammation, perception, modulation of pain and cardiovascular functions. ECS thus maintains balance in the nervous system and cannabinoids are the integral part of it.

It consists of:

  • cannabinoid receptors

  • endogenous cannabinoids (endocannabinoids)

  • transport proteins

  • enzymes (synthesize or degrade the endocannabinoids)

Research study on endocannabinoids (the cannabinoids our body produces inside) will be an essential part of the future development of CBD.

Mechanism of action

There are primarily two endocannabinoid receptors (CB1 and CB2) and CBD is active at both. While CB1 is found mostly in the brain and central nervous system, CB2 receptors are mainly expressed in immune cells in your body.

Although it cannot bind directly to CB1 receptor…

  • CBD increases the activity of the native endocannabinoid system by increasing cannabinoid receptor density.
  • It also inhibits FAAH (fatty acid amide hydrolase) which increases levels of endocannabinoids like the anandamide molecule.
  • CBD is also an agonist of the 5-HT1a serotonin receptor.

CBD acts on CB2 receptors to produce anti-inflammatory responses in brain immune cells.

It is very likely these CBD activities provides a well-known anti-anxiety and antidepressive effects.

systemic effects that CBD exerts

Does CBD work on GABA?
CBD is gabaergic ingredient so by its very nature it will have some sedative properties regardless of branding. Australian scientists report that CBD functions as a “positive allosteric modulator” of the GABA-A receptor. CBD lowers anxiety by changing the GABA-A receptor in such a way that enhances the natural calming impact of GABA. Research reveals CBD might increase overall rest amount and also lower sleeping disorders, as well as improve sleep in people that experience chronic pain.
 
How does CBD oil affect serotonin levels?
CBD can affect how your brain’s chemical receptors respond to the serotonin that’s already in your system. CBD has a suppressive effect on cytokine-induced tryptophan degradation. While increasing the tryptophan levels, which is a key compound in the serotonin synthesis pathway, that can lead to increased levels of serotonin.
 
Animal studies have demonstrated that CBD directly activates multiple serotonin receptors in the brain. Especially before mentioned 5-HT1a serotonin receptor. One 2014 animal study found that CBD’s effect on these receptors produced both antidepressive and anti-anxiety effects.
 
Does CBD affect dopamine?
CBD can interact with dopamine receptors, which play an essential role in managing lots of elements of behavior and cognition, consisting of motivation as well as reward-seeking behavior. There is demonstrated that CBD strongly modulates the mesolimbic dopamine (DA) system and may possess promising anti-psychotic properties (link).

CBD Nootropics Benefits And how it affects the brain?

CBD possesses a large range of wellness benefits. A lot of these benefits are related to cognitive efficiency. So, CBD is a superb natural nootropic compound as well. 

Brain fog affects overall mental performance but it’s not a disease. It’s an outcome of various other conditions within the body. CBD nootropics activity has been revealed to aid numerous medical conditions like insomnia, depression, inflammation, and stress, all of which may cause brain fog.

CBD works for all those symptoms due to its relationship with the endocannabinoid system. 

  • CBD is an antioxidant

That reduces the problems associated with oxygen stress influenced by our environment, toxins, food, stress and more. Memory loss and other brain deterioration indirectly lead to increased oxygen in the brain. CBD has the ability to reduce the toxic reactive oxygen species (ROS) formed during ischemic metabolism (link).

  • CBD can reduce inflammation

CBD may help reduce chronic inflammation and pain. Research has shown that it can reduce inflammation in the brain, as well as increase pain threshold, reduce pain intensity, and alter the perception of pain in adult participants (link1, link2).  

  • CBD can serve as a brain neuroprotectant

The neuroprotective potential of CBD is based on the combination of its anti-inflammatory and antioxidant properties. CBD may be able to positively affect the ECS and various brain signaling systems, hence it may help neurological disorders, such as epilepsy and multiple sclerosis (with oral spray Sativex®). In clinical trials, CBD has shown the ability to reverse and even prevent the development of Alzheimer’s negative impact on memory (link1, link2). 

  • CBD helps blood flow

CBD has long been used as a natural alternative to aid blood circulation thanks to its relaxing benefits. It aids to keep the brain healthy by bringing in nutrients and removing wastes (link).

  • CBD helps support the brain immune system

The endocannabinoid system (ECS) is so important because it keeps our body in balance. ECS responds to CBD compounds in therapeutic ways: CB2 receptors interact with the CBD and normalize functions of other systems. CBD oil may help your body’s ability to reduce inflammation and to fight infections (link). It may also have antibiotic benefits to aid recovery from bacterial infections (link). CBD also strengthens the microglial cells. Their job is to search and destroy various toxins like bacteria, viruses, fungus, and parasites from the brain (link).

  • CBD strengthens brain cells

CBD works on the brain cells by stimulating them and maintaining their energy levels. Since the mitochondria are the power store for cells, CBD oil keeps them active throughout the day. CBD appears to stimulate synaptic plasticity and facilitates hippocampal neurogenesis. That may explain its positive effects on attenuating psychotic, anxiety, and depressive behaviors (link). The mechanisms underlying these effects involve multiple cellular targets to elevate brain-derived neurotropic factor (BDNF) levels, reduce microglia activation, and decrease levels of proinflammatory mediators.

Does CBD help you focus?

CBD aids your focus by enabling extra serotonin to move in your brain in a similar manner as a selective serotonin reuptake inhibitor (SSRI). This enhanced serotonin triggers less anxiety and resulted in more focus.

CBD has even been shown to help improve the symptoms relating to attention deficit hyperactive disorder (ADHD). Those symptoms often include extreme lack of focus and concentration amongst other negative symptoms.

Novel CBD research

The researchers continue to prove that CBD is a powerful anti-epileptic, anti-depressant, anti-inflammatory, anti-nauseate, muscle relaxant, sleep aid, sedative, and anti-proliferative aid. As mentioned above, CBD has been shown to assist in several ways.

  • anxiety

  • clinical depression

  • stress

  • sleep quality

  • decreases addiction

Probably the most notable effects CBD exerts relate to anti-anxiety and antidepressant activity.

CBD Oil is anti-anxiety

In recent years, CBD has attracted increasing interest as a potential anxiolytic treatment. CBD has a broad pharmacological profile, including interactions with several receptors known to regulate fear and anxiety-related behaviors.

Several human studies with CBD have been conducted to show anti-anxiety effects are there because of the better regional cerebral blood flow (link).

The subjects in one study (2004) were given an oral dose of CBD (400 mg), and results suggested that CBD has anxiolytic properties mediated by an action on limbic and paralimbic brain areas.

Evidence from other human studies strongly supports the potential for CBD as a treatment for anxiety disorders at oral doses ranging from 300 to 600 mg (link).

CBD Oil is antidepressant

When it comes to treating depression, CBD has shown a promising effect compared to antidepressants. In one recent animal study, the data support a promising therapeutic profile for CBD as a new fast-acting antidepressant drug. These effects may be related through the activation of the BDNF signaling pathway which creates rapid changes in synaptic plasticity. Raising levels of serotonin through inhibiting 5-HT1a serotonin receptor activity is also responsible for an improvement in mood.

CB1, CB2 neuroreceptors are likely responsible for improvements in mood.

CBD also impact TRPV1 receptor that is involved in pain and stress response.

GPR55, 5-HT1-alpha, and adenosine A2A receptors can variously help with inflammation, pain, anxiety, and even potentially cancer.

CBD likely inhibiting the breakdown of endocannabinoids like anandamide molecule.

It also increases adenosine levels by inhibiting the adenosine transporter. It may all contribute to a better mood and reduce depression (link).

Does CBD help with addiction?

Substance use disorders are chronic recurrent conditions and the risk of relapse exists for a number of reasons, including craving caused by drug context, stress sensitivity, elevated anxiety, and impaired impulse control.
 
CBD does not appear to have an impact on stimulants’ rewarding effect, but one study suggests that it may influence addictive behaviors during the relapse phase. 
 
  • Cannabis

Consuming cannabis with higher levels of CBD causes less brain disruption, according to a new study from University College London. The researchers claim that the famously calming cannabinoid can protect against the harsher effects of THC. One case report has shown positive outcomes for a patient treated with CBD during the withdrawal and relapse phase of cannabis dependence (link).

  • Tobacco-related addictive behaviors 

The results of the human study showed a significant reduction in the number of cigarettes smoked (≈40%) in the CBD inhaler group (400 μg/inhalation) during the week of treatment, with a trend indicating a reduction after follow-up (link).

  • Heroin relapse

A recent double-blinded study published in the American Journal of Psychiatry, led by Yasmin Hurd, demonstrates the ability of CBD to reduce cravings in people with heroin drug addiction. The study involved 42 women and men with a history of heroin abuse attempting to abstain from relapse (link).

However, there is still limited evidence to support the use of CBD to treat drug addiction. The pre-clinical trials carried out are on animals and there are only a few human studies. No human study was found for opioid, psychostimulant, hallucinogen, or sedative-addictive behaviors.

CBD in the treatment of epilepsy?

The clinical use of CBD is the most advanced in the treatment of epilepsy. In the clinical experiments, CBD has proven to be an effective treatment for at least some forms of epilepsy, with one pure CBD product (Epidiolex®).

There is a number of studies in animals that demonstrated the anti-seizure activity of cannabidiol. Based on this research, cannabidiol was tested on patients with epilepsy. The Lennox-Gastaut and Dravet syndrome among others. A dose of CBD of 200-300 mg/day resulted in significant differences between the treatment and placebo groups.

A really inspiring story about a little girl with Dravet syndrome – a very rare syndrome of epilepsy – show us how CBD and cannabis oil works. Giving her a new hybrid strain of cannabis with a high level of CBD has made immediate results. This strain worked so well on stopping this little girl’s debilitating seizures, that today its name bears the name Charlotte’s web in honor of her.

Does CBD improve sleep?

Several studies from the last five years found an important effect that CBD has on sleep problems.
 
The study from 2014 tells us that CBD affects the sleep cycle. It found that CBD improved the symptoms of REM sleep behavior disorder (RBD) in patients with Parkinson’s disease.
 
Another study from 2014 found that CBD could have the potential to promote wakefulness, based on both human and animal research.
 
The study from 2017 elaborate that it shows the potential for treating excessive daytime sleepiness.
 
A 2018 research found that CBD soothes pain and thus can improve sleep. Finally, the new research from 2019 found that CBD could improve sleep and reduce anxiety.
 

Does CBD reduce stress?

In 2017 research nine healthy male volunteers were given 600 mg of CBD or placebo in a randomized, placebo-control, double-blind, crossover study. Cardiovascular parameters were monitored using a finometer and laser Doppler. The results show that a single dose of CBD reduces resting blood pressure and the blood pressure response to stress, particularly cold stress, and especially in the post-test periods.
 
Studies indicate that CBD may be able to help with high blood pressure. This may reflect the anxiolytic and analgesic effects of CBD, as well as any potential direct cardiovascular effects.
 

Can CBD help MS symptoms?

According to the American Academy of Neurology, the use of oral cannabis extract (OCE) and synthetic THC improved spasticity-related symptoms and pain in patients with Multiple Sclerosis (link).
 

Can CBD reverse brain damage?

A new brain imaging study suggests that a single dose of CBD can reduce symptoms of psychosis by “resetting” activity in three brain areas. THC is small doses that can be used both to treat and prevent brain swelling as well as other neurodegenerative issues without provoking any sort of psychoactive effect (link).
 

Discovering the different forms of CBD

When looking at CBD products, the main difference you’ll see in labelling are the following categorizations:
 
  • Whole spectrum

  • Full spectrum 

  • Broad spectrum

  • CBD isolate

 

Whole spectrum

The science suggests that we absorb things better in their natural form. For CBD, the ”whole plant” products utilise the entire spectrum of hemp compounds. Hemp is rich in over 40 different cannabinoids, as well as essential terpenes, flavonoids, waxes and oils. As a result of the so called ‘entourage effect’ there is an agreement between experts that CBD whole plant products works much better than an isolated CBD compound. 
 

Full spectrum

Like whole plant, full spectrum CBD covers full range of cannabinoids, terpenes and flavonoids, but without the waxes, oils and additional fibrous substances. This makes full spectrum CBD a smoother and easier to vipe. Full spectrum CBD usually causes more sedation in my experience than CBD isolate oil. This is due to additional cannabinoids, including very low levels of THC, CBN, and various terpenes that are present in the full-spectrum formulations other than CBD alone.

Broad spectrum

Broad spectrum CBD means that it retains the additional cannabinoids, terpenes and flavonoids in full spectrum, whilst removing all traces of THC. That makes it the safest choice. Some people even react to the trace amount of THC so this kind of products is for them. Also, broad spectrum CBD don’t interfere with drug tests.

CBD isolate

Isolated CBD is 99.9% pure CBD where cannabinoids, terpenes, waxes and oils are removed. This works best in a products like topical creams, where CBD is supported by other organic oils. It’s typically made use of medicinally, not recreational, with the 4 most frequently targeted conditions being pain, anxiety, depression, and sleep disorders. Purified CBD has limited industrial usefulness because its effective dose is narrow and difficult to pinpoint. It’s effectiveness peaks at a medium dose and tapers off for higher doses and lower doses — which graphically looks like an inverted “U” or a bell. This is known as the bell-shaped response curve

Ways to take CBD

There are several different ways that you may try CBD. Each of these solutions has a specific effect to help you with various conditions.

When it comes to CBD, the oral bioavailability is much lower than it’s sublingual and vaporized forms. Vaping CBD seems to be the least effective form of CBD. CBD sprays are usually the weakest concentration compared to other forms of CBD.

Sublingual Tinctures, concentrates, soft gels, gems

Oral products such as our soft gels, tinctures, and gems have a systemic effect, meaning they work on your whole body. Many customers start with 25mg soft gel capsule and slowly increase in 25mg increments until finding their ideal dosage. Capsules are ideal for keeping track of your daily dosage. Also, you can just add the CBD capsules to your nootropic stack.

Tinctures are the most common form of CBD on the market. And likely the most pure form of CBD. Dosages range from 100 – 1000 mg. By sublingual tinctures method, you consume CBD oil by placing it under your tongue and holding it there for up to a minute prior to ingesting. This approach has been proven to be very discreet and efficient in calming some chronic pain quickly. It is a convenient method that requires no extra accessories and has long-lasting effects. If you want to avoid oil tinctures that contain alcohol, look for the ones that are made of vegetable glycerin.

CBD concentrate is a high potency extract of the hemp plant that contains an incredibly high percentage of CBD. Concentrates are similar to herbal extracts in that they can contain up to 10-times the concentration of CBD compared to a tincture. Similar to tinctures, concentrates of CBD work well sublingually or can be used to make edibles containing high doses of cannabidiol. 

Ingestion

Some people even use CBD oil in cooking or add a few drops to their favorite smoothie, drink and/or food recipe. Some pre-made products bring CBD into a chewable gummy, bears or lollipops, so you don’t even have to add them to your meal. You can also make CBD edible products yourself without buying them pre-made. Be careful, however, how much oil you use.

Topical application

This method is basically applying CBD through a lip balms, lotions, salves, or as an ointment on the skin. It’s easiest because it doesn’t require special tools. It can be effective in muscle pain, acne, sore throat, back pain, and migraines. You should read the label to find out what type of technology the product employs to deliver CBD through the dermal layers of your skin.

Inhalation

This is the most effective and fastest method as CBD enters the bloodstream through your lungs. Smoking and vaping are two methods of inhalation. Notice that these two methods are also the least healthy ways to take CBD. They pose significant health risks which must be cautiously weighed against the limited substantiated therapeutic benefits of cannabis.

If you decide to try vaping CBD, experts advise to ensure you avoid vape juice or vape pens using propylene glycol as a carrier. It’s because of toxins that produces when propylene glycol is heated.

Instead, you may vaporize CBD concentrates, a process known as dabbing. It has been recently growing in popularity amongst cannabis and CBD enthusiasts. Dabbing is an extremely effective delivery system for administering high doses of CBD in a relatively short period of time.

CBD oil Concentration and Nootropic dosage

To find out how much CBD remains in your oil product, discover the complete CBD or cannabinoid content as well as the volume of the bottle. For instance, your 25 ml tincture may have 500 mg CBD total amount. Next off, you will want to divide this total by the bottle quantity (500/25), which in our example results in 20 mg.

This means 1 ml of your CBD oil includes 20 mg of CBD. A lot of droppers have a volume of 1 ml when they are full and have an overall of 20 drops. This means we can divide our 20 mg by 20 – the number of drops. In our instance, one drop of oil has 1 mg of CBD.

It is difficult to give a precise CBD nootropic dosage because of several variables such as:

  • What you’re taking CBD for?

  • Your body weight

  • The form of CBD

  • how your body reacts to cannabidiol

As a general guideline, you ought to begin with very low doses such as 5 mg and increase until you experience the wanted impacts.

For nootropic uses, the majority of people make use of 15-50 mg dosages of CBD in oil form.

Side Effects - Very low toxicity of CBD in humans

Unlike the psychoactive properties associated with Δ9-THC, CBD has been shown to have very low toxicity in humans and in other species. Ingested and absorbed CBD is rapidly distributed, and due to its lipophilic nature can easily pass the blood–brain barrier. The terminal half-life of CBD is about 9 h and is preferentially excreted in the urine as its free and glucuronide form. (link)

CBD has an excellent safety profile. Noted adverse side-effects may only be as a result of CBD and other plant cannabinoids interaction with many pharmaceuticals.

To date, there is no evidence of recreational use of CBD or any public health-related problems connected with using pure CBD.

I also haven’t read that biohackers complained about any type of undesirable impacts of CBD oils they use. There are no deadly dose of CBD or THC. Generally is more efficient to take reduced than greater dosages if you are healthy and in shape.

Researches have been concluded that approximately a 700 mg of CBD day-to-day doses fell short to cause any considerable change in neurological, psychiatric or clinical tests.

The adverse effects are known to be caused by low quality products from unreliable brands. You must always search for the COA certification because all earth-grown products soaks up toxic substances like mercury and lead.

FAQ

It’s unlikely you can take enough CBD oil to endanger your health. Studies have found that in some people CBD can cause diarrhea, changes in appetite, and fatigue. Follow the dosage directions to get the best results.

CBD is thought to have antipsychotic effects, and the greatest evidence for its antipsychotic ability is to block THC-induced psychosis.

CBD does not result in sensations of sleepiness or drowsiness. However, individual responses to CBD can be various. Some people report sensations of “being energized” after taking CBD, while others report sensations of “relaxation.” Research show that CBD can assist individuals with insomnia to relax and therefore fall and remain asleep. Nevertheless, CBD oil made from hemp does not have intoxicating properties, meaning that it should not make you feel tired, sleepy or otherwise sedated.

Cannabidiol (CBD) shouldn’t show up on a drug test. However, many CBD products contain trace amounts of delta-9-tetrahydrocannabinol (THC), marijuana’s main active ingredient. If enough THC is present, it will show up on a drug test. This means that in rare cases, using CBD might lead to a positive drug test. For that matter it is better to use broad spectrum CBD products that removes all traces of THC, as well as additional cannabinoids.

Alcohol and CBD intake could exacerbate these effects, potentially causing symptoms such as increased drowsiness and sedation. Mixing them can result in mood and behavior changes.
The brief, straightforward answer is no. Yet, given that various CBD products include differing levels of THC, the matter is a little complicated. At the molecular level, CBD is neither habit forming, nor does it produce the so-called stoned effect that THC does. Though, if somebody takes big amounts of CBD on daily basis, it could experience negative effects when stopping.

Nootropic blend Recommendation

“The brain is about a symphony, and CBD can bring the entire symphony into harmony.”

Yasmin Hurd, PhD, director of the Addiction Institute at Mount Sinai

With all the supplements that have antioxidant and neuroprotective properties and also improve learning or focus, choosing CBD would be a legitimate option. For those with anxiety, it’s a much better choice than choosing a racetam stack or other herbals. And, also, many people in pursuit of a good sleep aid are thrilled with the CBD.

The only question that arises is would a CBD isolate without all the other ingredients still work as strong for you? Sometimes CBD Isolate works better than for example full-spectrum CBD oil. I’ve also found that a full-flower CBD extract of a high CBD strain for some people works better than CBD isolate. Try both and see which one works better for you?
 
If you are a nootropics beginner, it is safe to start with CBD oil of 5 – 50 mg daily. By gradually increasing the dose you will eventually find your sweet spot.
 
If you are looking for the best vendors that sell CBD oils, there are more and more good companies. I would recommend you to know your CBD source which is best to be an independent, third party-certified CBD, grown as well with organic inputs and without pesticides. User reviews can be especially helpful in choosing a high quality CBD supplier.
 
I highly recommend Nootropics Depot nextCBD hemp extract. It is 20x more bioavailable and fully water-soluble, unlike the regular CBD. That means you can use less and get more from its effects. You can have it in the form of soft gel capsules and oral drops.
 
Also, two formulas by Natural Stacks, Omega CBD™ and Dream CBD™ , are also a great full-spectrum hemp extracts. Omega CBD helps to ease daily tension, soothes pains as well as discomforts. While Dream CBD will assist you to fall asleep swiftly, to remain asleep all night, as well as to recover because of deep, restorative sleep.
 
If you are seeking pre-made stacks loaded with top quality CBD, the Nootripure’s Laboratories products are one that contains the most bioavailable source of cannabidiol stacked with various other A-grade nootropics. Their patented CBD, called Nootriplex, is something that made difference and refine the level of their blends.
 
Now that you’ve broken the taboo’s about CBD and learned enough to get you started, it’s your turn to take action.
 
Explore and don’t forget to click the share button below if this article was of any help. 

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