Unlock Your Brain’s Potential with CBD Nootropics

logo nootropicblend.com
By Nootropic Blend staff

Table of Contents

Taboos you should break about CBD

What is CBD?

Cannabidiol was isolated from cannabis extracts by American chemist Roger Adams. However, no further investigation was carried out for almost 25 years, except for a few studies about its isolation. The exact chemical structure of CBD was elucidated only in 1963 by the group of Professor Raphael Mechoulam, from the Hebrew University of Jerusalem in Israel. Throughout the 1960s, the same group was responsible for the determination of the precise structure and stereochemistry of Δ9-THC and other major cannabinoids. These findings opened a new research field on the pharmacological activity of cannabis constituents. Before the 1970s, only a few pharmacological studies on CBD had been made, which concluded that CBD had no cannabis-like activity, as opposed to Δ9-THC (link).

brief history of cannabidiol

Cannabidiol can be drawn out from three sources:

  • marijuana

  • hemp

  • synthesized in the lab 

CBD is one of the 120 phytocannabinoids discovered in the cannabis species (Sativa and Indica). The cannabis plant has two key types, hemp (sativa) and marijuana (indica). Both have CBD, yet there’s a much higher percentage in hemp, which additionally has very reduced (less than 0.3%) degrees of delta-9-tetrahydrocannabinol (THC) compared to marijuana. That’s why CBD from hemp won’t get you ‘high’.

Cannabis Sativa L. plant, a breed of hemp, is designed to minimize THC and maximize CBD so that it consists of around 40% of the plant’s active substances. 

For less complicated tracking of this article, have a look at this graphic and discover exactly how CBD oil is gotten.

graphic show the CBD oil origins from the cannabis plant

CBD Oil vs. Hemp seed Oil difference

CBD oil makes use of the whole plant, while hemp oil originates from its seeds. Cannabis CBD extracts primarily come from the flowers and leaves of the marijuana plant. And from the flowers, leaves, and stalks of the hemp plant.

  • Hemp seed oil is not CBD oil

When individuals speak about hemp oil, they’re referring to oil removed from the seeds of the hemp plant. There are no cannabinoids, CBD, or THC, in hemp seed oil. Yet CBD oil is sometimes used to describe hemp seed oil, which consists of no active CBD. This component is loaded only with healthy fats and usually appears in beauty products for its hydrating benefits.

  • The hemp plant’s leaves and flowers are one resource of CBD oil

The term “hemp oil” frequently is made use of to refer to the CBD-rich product removed from the flowers and leaves of the hemp plant. Some full-spectrum CBD oral drops use hemp seed oil as a carrier oil, as it is considered to be one of the most beneficial oils available.

Endocannabinoid System relationship with CBD

Although cannabinoids were first found in the cannabis plant, they in fact exist in a whole host of various other biological systems, including our own.

When the endocannabinoid system is first discovered in 1992, it is found to be important to human health and well-being through maintaining homeostasis (balance) in various aspects of physiology. In essence, homeostasis regulates all major body systems, ensuring they all work alongside one another.

ECS affects everything from learning and memory, mood and anxiety, drug addiction, appetite, inflammation, perception, modulation of pain, and cardiovascular functions. ECS thus maintains balance in the nervous system and cannabinoids are an integral part of it.

It consists of:

  • Cannabinoid receptors

  • Endogenous cannabinoids (endocannabinoids)

  • Transport proteins

  • Enzymes (synthesize or degrade the endocannabinoids)

Research study on endocannabinoids (the cannabinoids our body produces inside) will be an essential part of the future development of CBD.

Mechanism of action

There are primarily two endocannabinoid receptors (CB1 and CB2) and CBD is active at both. While CB1 is found mostly in the brain and central nervous system, CB2 receptors are mainly expressed in immune cells in your body.

Although it cannot bind directly to the CB1 receptor…

  • CBD increases the activity of the native endocannabinoid system by increasing cannabinoid receptor density.

  • It also inhibits FAAH (fatty acid amide hydrolase), which increases levels of endocannabinoids like the anandamide molecule.

  • CBD is also an agonist of the 5-HT1a serotonin receptor.

CBD acts on CB2 receptors to produce anti-inflammatory responses in brain immune cells.

It is very likely these CBD activities provide well-known anti-anxiety and antidepressive effects.

Systemic effects that CBD exerts

Does CBD work on GABA?
CBD is a gabaergic ingredient so by its very nature, it will have some sedative properties regardless of branding. Australian scientists report that CBD functions as a “positive allosteric modulator” of the GABA-A receptor. CBD lowers anxiety by changing the GABA-A receptor in such a way that enhances the natural calming impact of GABA. Research reveals CBD might increase overall rest amount and lower sleeping disorders, as well as improve sleep in people that experience chronic pain.
How does CBD oil affect serotonin levels?
CBD can affect how your brain’s chemical receptors respond to the serotonin that’s already in your system. CBD has a suppressive effect on cytokine-induced tryptophan degradation. While increasing the tryptophan levels, which is a key compound in the serotonin-synthesis pathway, can lead to increased levels of serotonin.
Animal studies have demonstrated that CBD directly activates multiple serotonin receptors in the brain. Especially before mentioned 5-HT1a serotonin receptor. One 2014 animal study found that CBD’s effect on these receptors produced both anti-depressive and anti-anxiety effects.
Does CBD affect dopamine?
CBD can interact with dopamine receptors, which play an essential role in managing lots of elements of behavior and cognition, consisting of motivation as well as reward-seeking behavior. There is demonstrated that CBD strongly modulates the mesolimbic dopamine (DA) system and may possess promising antipsychotic properties (link).

CBD nootropics Benefits

“The brain is about a symphony, and CBD can bring the entire symphony into harmony.”

Yasmin Hurd, PhD, director of the Addiction Instit

CBD possesses a large range of wellness benefits. A lot of these benefits are related to cognitive efficiency. So, CBD is one of the superb natural nootropic compounds as well. 

Brain fog affects overall mental performance, but it’s not a disease. It’s an outcome of various other conditions within the body. CBD nootropic activity has been revealed to aid numerous medical conditions like insomnia, depression, inflammation, and stress, all of which may cause brain fog.

CBD works for all those symptoms due to its relationship with the endocannabinoid system. 

  • CBD is an antioxidant

That reduces the problems associated with oxygen stress influenced by our environment, toxins, food, stress, and more. Memory loss and other brain deterioration indirectly lead to increased oxygen in the brain. CBD has the ability to reduce the toxic reactive oxygen species (ROS) formed during ischemic metabolism (link).

  • CBD can reduce inflammation

CBD may help reduce chronic inflammation and pain. Research has shown that it can reduce inflammation in the brain, as well as increase pain threshold, reduce pain intensity, and alter the perception of pain in adult participants (link1, link2).  

  • CBD can serve as a brain neuroprotective

The neuroprotective potential of CBD is based on the combination of its anti-inflammatory and antioxidant properties. CBD may be able to positively affect the ECS and various brain signaling systems, hence it may help neurological disorders, such as epilepsy and multiple sclerosis (with oral spray Sativex®). In clinical trials, CBD has shown the ability to reverse and even prevent the development of Alzheimer’s negative impact on memory (link1, link2). 

  • CBD helps blood flow

CBD has long been used as a natural alternative to aid blood circulation thanks to its relaxing benefits. It aids to keep the brain healthy by bringing in nutrients and removing wastes (link).

  • CBD helps support the brain-immune system

The endocannabinoid system (ECS) is so important because it keeps our bodies in balance. ECS responds to CBD compounds in therapeutic ways: CB2 receptors interact with the CBD and normalize functions of other systems. CBD oil may help your body’s ability to reduce inflammation and fight infections (link). It may also have antibiotic benefits to aid recovery from bacterial infections (link). CBD also strengthens the microglial cells. Their job is to search and destroy various toxins like bacteria, viruses, fungus, and parasites from the brain (link).

  • CBD strengthens brain cells

CBD works on the brain cells by stimulating them and maintaining their energy levels. Since the mitochondria are the power store for cells, CBD oil keeps them active throughout the day. CBD appears to stimulate synaptic plasticity and facilitates hippocampus neurogenesis. That may explain its positive effects on attenuating psychotic, anxiety, and depressive behaviors (link). The mechanisms underlying these effects involve multiple cellular targets to elevate brain-derived neurotrophic factor (BDNF) levels, reduce microglia activation, and decrease levels of pro-inflammatory mediators.

Does CBD help you focus?

CBD aids your focus by enabling extra serotonin to move in your brain similar to a selective serotonin reuptake inhibitor (SSRI). This enhanced serotonin triggers less anxiety and resulted in more focus.

CBD has even been shown to help improve the symptoms relating to attention deficit hyperactive disorder (ADHD). Those symptoms often include extreme lack of focus and concentration amongst other negative symptoms.

Different forms of CBD

When looking at CBD products, the main difference you’ll see in labeling are the following categorizations:
  • Whole spectrum

  • Full-spectrum 

  • Broad-spectrum

  • CBD isolate


Whole spectrum

Science suggests that we absorb things better in their natural form. For CBD, the ”whole-plant” products utilize the entire spectrum of hemp compounds. Hemp is rich in over 40 different cannabinoids, as well as essential terpenes, flavonoids, waxes, and oils. As a result of the so-called ‘entourage effect,’ there is an agreement between experts that CBD whole plant products work much better than an isolated CBD compound. 


Like the whole plant, full-spectrum CBD covers the full range of cannabinoids, terpenes, and flavonoids, but without the waxes, oils, and additional fibrous substances. This makes full-spectrum CBD smoother and easier to vape. Full-spectrum CBD usually causes more sedation in my experience than CBD isolate oil. This is due to additional cannabinoids, including very low levels of THC, CBN, and various terpenes that are present in the full-spectrum formulations other than CBD alone.


Broad-spectrum CBD means that it retains the additional cannabinoids, terpenes, and flavonoids in full-spectrum, whilst removing all traces of THC. That makes it the safest choice. Some people even react to the trace amount of THC, so this kind of product is for them. Also, broad-spectrum CBD doesn’t interfere with drug tests.

CBD isolate

Isolated CBD is 99.9% pure CBD where cannabinoids, terpenes, wax, and oils are removed. This works best in products like topical creams, where CBD is supported by other organic oils. It’s typically made use of medicinally, not recreational, with the 4 most frequently targeted conditions being pain, anxiety, depression, and sleep disorders. Purified CBD has limited industrial usefulness because its effective dose is narrow and difficult to pinpoint. Its effectiveness peaks at a medium dose and tapers off for higher doses and lower doses — which graphically look like an inverted “U” or a bell. This is known as the bell-shaped response curve. 
970X250 Optimized JPG1

Ways to take CBD

There are several ways that you may try CBD. Each of these solutions has a specific effect to help you with various conditions.

When it comes to CBD, the oral bioavailability is much lower than its sublingual and vaporized forms. Vaping CBD seems to be the least effective form of CBD. CBD sprays are usually the weakest concentration compared to other forms of CBD.

 Sublingual Tinctures, concentrates, soft gels, gems

Oral products such as our soft gels, tinctures, and gems have a systemic effect, meaning they work on your whole body. Many customers start with 25 mg soft gel capsules and slowly increase in 25 mg increments until finding their ideal dosage. Capsules are ideal for keeping track of your daily dosage. Also, you can just add the CBD capsules to your custom nootropic stack.

Tinctures are the most common form of CBD on the market. And likely the purest form of CBD. Dosages range from 100 to 1000 mg. By the sublingual tinctures method, you consume CBD oil by placing it under your tongue and holding it there for up to a minute before ingesting it. This approach has been proven to be very discreet and efficient in calming some chronic pain quickly. It is a convenient method that requires no extra accessories and has long-lasting effects. If you want to avoid oil tinctures that contain alcohol, look for ones that are made of vegetable glycerin.

CBD concentrate is a high-potency extract of the hemp plant that contains an incredibly high percentage of CBD. Concentrates are similar to herbal extracts in that they can contain up to 10 times the concentration of CBD compared to a tincture. Similar to tinctures, concentrates of CBD work well sublingual or can be used to make edibles containing high doses of cannabidiol


Some people even use CBD oil in cooking or add a few drops to their favorite smoothie, drink, and/or food recipe. Some pre-made products bring CBD into chewable gummy, bears, or lollipops, so you don’t even have to add them to your meal. You can also make your own CBD edibles if you don’t want to buy them in the pre-made stack solutions. Be careful, however, how much oil you use.

 Topical application

This method is basically applying CBD through lip balms, lotions, salves, or as an ointment on the skin. It’s easier because it doesn’t require special tools. It can be effective in muscle pain, acne, sore throat, back pain, and migraines. You should read the label to find out what type of technology the product employs to deliver CBD through the dermal layers of your skin.


This is the most effective and fastest method as CBD enters the bloodstream through your lungs. Smoking and vaping are two methods of inhalation. Notice that these two methods are also the least healthy ways to take CBD. They pose significant health risks, which must be cautiously weighed against the limited substantiated therapeutic benefits of cannabis.

If you decide to try vaping CBD, experts advise ensuring you avoid vape juice or vape pens using propylene glycol as a carrier. It’s because of toxins that produce when propylene glycol is heated.

Instead, you may vaporize CBD concentrates, a process known as dabbing. It has been recently growing in popularity amongst cannabis and CBD enthusiasts. Dabbing is an extremely effective delivery system for administering high doses of CBD in a relatively short period of time.

CBD oil Concentration and Nootropic dosage

To find out how much CBD remains in your oil product, discover the complete CBD, or cannabinoid content as well as the volume of the bottle. For instance, your 25 ml tincture may have 500 mg CBD total amount. Next off, you will want to divide this total by the bottle quantity (500/25), which in our example results in 20 mg.

This means 1 ml of your CBD oil includes 20 mg of CBD. A lot of droppers have a volume of 1 ml when they are full and have an overall of 20 drops. This means we can divide our 20 mg by 20 – the number of drops. In our instance, one drop of oil has 1 mg of CBD.

It is difficult to give a precise CBD nootropic dosage because of several variables such as:

  • What you’re taking CBD for?

  • Your body weight

  • The form of CBD

  • How your body reacts to cannabidiol

As a general guideline, you ought, to begin with very low doses such as 5 mg and increase until you experience the wanted impacts.

For nootropic uses, the majority of people make use of 15-50 mg dosages of CBD in oil form.

Legality of CBD

Nootropic blend Recommends CBD

728X90 PNG

With all the supplements that have antioxidant and neuroprotective properties and improve learning or focus, choosing CBD would be a legitimate option. For those with anxiety, it’s a much better choice than choosing a racetam stack or other herbals. And, also, many people in pursuit of a good sleep aid are thrilled with CBD.

The only question that arises is would a CBD isolate without all the other ingredients still work as strong for you? Sometimes CBD Isolate works better than for example full-spectrum CBD oil. I’ve also found that a full-flower CBD extract of a high CBD strain for some people works better than a CBD isolate. Try both and see which one works better for you?
If you are a beginner, it is safe to start with CBD oil of 5 – 50 mg daily. By gradually increasing the dose, you will eventually find your sweet spot.
If you are looking for the best vendors that sell CBD oils, among other nootropics, there are more and more good companies. I would recommend you know your CBD source which is best to be an independent, third-party-certified CBD, grown as well with organic inputs and without pesticides. User reviews can be especially helpful in choosing a high-quality CBD supplier.
One of the best such suppliers is Liftmode Hemp where you can find a growing list of the best CBD products. If interested, don’t forget to use our gift code Nootropic_Blend to get 10% off entire order.
We also recommend two formulas by Natural Stacks, Omega CBD™, and Dream CBD™, which are great full-spectrum extracts. Omega CBD helps to ease the daily tension, soothes pains as well as discomforts. While Dream CBD will assist you to fall asleep swiftly, to remain asleep all night, as well as to recover because of deep restorative sleep.
If you are seeking a CBD nootropic stack loaded with top-quality CBD, the Nootripure’s Laboratories products are one that contains the most bioavailable source of cannabidiol stacked with various other A-grade natural nootropics. Their patented CBD, called Nootriplex, is something that made a difference and refines the level of their blends. 
Now that we’ve broken all the taboos about CBD, it’s your turn to take action and reap the benefits of this wonderful substance.

Pick up nootropics that best reflect your goal

Read our next article to get you started

Best natural nootropics

Leave a Comment