- Nootropic Blend staff
- Updated October 31, 2023
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In the quest for optimal health and longevity, selecting the top NMN (Nicotinamide Mononucleotide) supplement brands is a crucial step. These brands stand out for their commitment to purity, potency, and quality, providing you with the best tools to support your cellular health and overall well-being. Let’s delve into the world of NMN supplements and discover the leading names in the industry.
Table of Contents
Understanding NMN and Choosing a Supplier
When you’re on the hunt for the best NMN supplement brands, a host of critical factors should shape your choice:
1. Purity, Potency, Source, and Formulation: These factors significantly influence the supplement’s effectiveness and safety.
2. NMN’s Role in Cellular Function: NMN is a fundamental building block of DNA and a key player in metabolic processes. Within your cells, NMN undergoes conversion into nicotinamide adenine dinucleotide (NAD+), a cornerstone for cellular metabolism and energy production.
3. NAD+ Utilization: NAD+ serves as a substrate for various enzymes, including PARPs, DNA repair mechanisms, and sirtuins residing in different cellular compartments. However, the conversion of NAD+ into nicotinamide (NAM) isn’t always straightforward and can hinder sirtuins and PARPs at elevated doses.
4. NMN vs. NAD+: NMN is an immediate precursor to NAD+ and is vital for elevating NAD+ levels in cells, offering better bioavailability. In contrast, NAD+ is composed of two nucleotides, acts as an electron carrier in metabolic pathways, and is less efficiently absorbed when taken orally.
5. Benefits and Anti-Aging: Clinical studies suggest that boosting NAD+ levels through NMN and NAD+ precursors may positively impact health and longevity. Your choice between NMN and NAD+ supplementation often comes down to factors like bioavailability, ease of use, and personal preferences.
6. NMN vs. NR: NMN and NR are both NAD+ precursors with the ability to safely raise NAD+ levels. Different tissues and organs may have preferences for one precursor over the other.
7. NMN Delivery Methods: NMN supplements are available in various delivery methods. Sublingual NMN is fast but has dose and duration limits. Intranasal NMN has potential but lacks conclusive research. Oral NMN in capsules or powders is effective. Liposomal NMN may enhance absorption but could disrupt natural absorption regulation, so consider combining it with other methods for higher doses. Intravenous NAD+ therapy is effective but expensive.
8. Third-Party Lab Testing: For the average consumer, third-party lab testing and accessible lab reports are essential for confidence in product quality.
9. Affordability, Efficacy, and Customer Service: These play pivotal roles in brand choices.
10. Personal Preferences: Consider the type of NMN supplement that suits you best, whether it’s in powder, capsule, or enteric-coated tablet form, based on your personal preferences and absorption concerns.
Consider these essential factors to make an informed decision in your pursuit of a healthier and longer life. Rest assured, we’ve taken all these criteria into account to bring you our 5 best NMN supplement brand recommendations for 2023. Let’s explore these top choices together.
NMN Supplement brand #1 - Renue By Science
NAD⁺ Complete by Renue By Science is a groundbreaking supplement designed to support overall health and longevity. This comprehensive 4-in-1 supplement combines NAD⁺, NMN, NR, and niacin, simplifying your daily supplement routine. What sets NAD⁺ Complete apart is its utilization of cutting-edge liposomal delivery technology.
This innovative method significantly enhances the absorption of these vital compounds, providing up to six times better bioavailability compared to traditional supplements. Moreover, the liposomal delivery system reduces the risk of potential liver-related issues, allowing for the safe consumption of more effective dosages.
Individual responses to supplements can vary, influenced by factors such as age, overall health, and lifestyle. While both NAD+ and NMN are essential for cellular energy production, some users have reported distinct experiences with NAD⁺ Complete. Users have found relief from joint pain and improved sleep quality while using the liposomal versions of these supplements. This enhanced bioavailability may contribute to these positive effects.
Switching to liposomal NMN and NAD+ formulations, like those offered by Renue By Science, has been reported to result in sustained energy throughout the day and potentially more regular circadian rhythms. The traditional powder forms of these compounds, while effective, tend to provide a more immediate “boost” of energy. This shift to a smoother, more subtle energy boost can be a desirable outcome for individuals seeking sustained vitality. Additionally, some users have taken NAD level tests and reported improved NAD levels after using liposomal supplements.
Ultimately, the choice between traditional powder and liposomal supplements may depend on individual preferences and desired outcomes. The convenience, absorption efficiency, and reported benefits of liposomal NMN and NAD+ supplements, such as those from Renue By Science, make them an attractive option for individuals looking to support their overall well-being and vitality.
What customers say about Renue By Science
Users on Reddit largely express trust in Renue by Science as a supplier of NMN supplements, citing its legitimacy and quality. Some users mention that Renue has been mentioned by well-known figures such as Andrew Huberman. However, there are a few comments suggesting that customer service and communication could be improved, and the pricing of their products has been a point of discussion, especially for international customers.
Pros
- Offers NMN in wide variety of forms and formulations
- Third-party tested for purity and safety (over 99% purity)
- Manufactured in an FDA-approved facility with cGMP certification
- Vegan-friendly, with no artificial additives
- Maximizes nutrient absorption for optimal results
Cons
- No return policy for opened/used products
NMN Supplement brand #2 - Purovitalis
Purovitalis is a European-based company renowned for its high-purity NMN supplements, boasting an impressive 99% purity. These supplements are manufactured in GMP-certified facilities, ensuring quality and safety. Purovitalis uses liposomal technology to enhance the bioavailability of their NMN capsules, with each serving containing 250 mg of NMN. The recommended daily dosage is two capsules.
Purovitalis offers a range of options, including 30, 60, or 120 capsule quantities. They also provide pure NMN powder in bottles ranging from 15 to 120 grams. For those seeking a combination of NMN and resveratrol, Purovitalis offers a bundle designed for a 2-month supply. They provide worldwide shipping at reasonable rates, with $6.99 standard shipping available in the USA, and an express delivery option for $14.99.
Customers who have used Purovitalis NMN supplements have reported increased energy, better sleep, enhanced skin health, and quicker recovery after workouts. Purovitalis prioritizes purity, transparency, and safety, conducting third-party testing to maintain the highest quality.
Their NMN is sourced from a reputable European manufacturer, and their products are produced in cGMP-certified facilities. They offer various capsule quantities and a subscription option for savings, all backed by a 30-day money-back guarantee.
In summary, Purovitalis is a top choice for individuals seeking pure and effective NMN supplements to support their longevity and overall health journey.
What customers say about Purovitalis
Customers on Trustpilot have praised Purovitalis for efficient delivery, positive product experiences, and good customer service, with some noting noticeable energy and health benefits from the products.
Pros
- Impressive 99% purity, reflecting their commitment to quality
- High absorption rate
- No unwanted additives – it's pure NMN through and through
- UV Protection Glass Containers
Cons
- Slightly Higher Price Tag
- Lower Dosage per Capsule
NMN Supplement #3 - DoNotAge
DoNotAge (DNA), a UK-based company that offers a pure β-Nicotinamide Mononucleotide (β-NMN) supplement with a remarkable 99% purity, containing 1000 mg (1 g) of NMN per serving. This is delivered in the form of two non-liposomal capsules. DoNotAge stands out by providing the highest amount of NMN per serving compared to other products on the market, making it a potent choice. Their product is vegan-friendly and free from artificial ingredients, allergens, and preservatives.
DoNotAge’s NMN capsules contain 500mg of non-liposomal NMN and are manufactured by Uthever, a well-known NMN producer from China. While the capsules are slightly larger due to the high NMN content, they may pose a challenge for some individuals to swallow. Each package includes 60 capsules, equivalent to a one-month supply, and is well-sealed to maintain product quality.
Quality and safety are paramount to DoNotAge, as the product undergoes regular third-party testing, and is manufactured in a GMP-certified facility. The ISO9001 standards are also adhered to during production.
DoNotAge’s NMN supplement is available exclusively on its official website, and it is not sold on Amazon in the US. While the price is somewhat above average compared to other NMN providers, DoNotAge’s commitment to providing high-quality NMN with transparency and testing ensures their product’s reliability and effectiveness.
What customers say about DoNotAge
The Trustpilot reviews of DoNotAge, a health supplement company, reflect a range of opinions. Many customers express satisfaction with the product quality, prompt delivery, and customer service. They report positive health effects, from improved skin to reduced inflammation. Some praise the company’s concise product selection and transparency. However, a few negative reviews mention concerns about misleading advertising, suggesting that the company may need to improve its transparency and communication.
Pros
- High NMN purity and potency
- Good manufacturing standards
- Vegan-Friendly
- Non-Liposomal option for those with specific preferences
Cons
- Slightly above average in terms of cost
- The capsules are larger than regular ones
NMN Supplement #4 - ProHealth Longevity
ProHealth Longevity offers a range of NMN (Nicotinamide Mononucleotide) supplements designed to promote overall well-being and potentially support anti-aging efforts. These supplements feature high-quality NMN as the primary ingredient, with a focus on enhancing NAD+ (Nicotinamide Adenine Dinucleotide) levels in the body.
ProHealth Longevity’s NMN products come in various forms, such as capsules, powders, tablets, and lozenges, providing flexibility in how users choose to incorporate NMN into their daily routines. These supplements are known for their pharmaceutical-grade quality and purity, having undergone third-party testing to ensure potency and absence of heavy metals.
Users of ProHealth Longevity NMN supplements have reported benefits like increased energy levels, improved cognitive function, and potential anti-aging effects. The formulations also include additional beneficial components like vitamin D, Bioperine, Ergothioneine, and Hydroxytyrosol.
For individuals looking to elevate their NAD+ levels and potentially experience improvements in cellular function, cognitive performance, and overall vitality, ProHealth Longevity NMN products offer a trusted and comprehensive range of options. Additionally, ProHealth Longevity provides discounts, money-back guarantees, and free shipping, making these supplements accessible to those seeking to support their health and well-being.
What customers say about ProHealth
Customers’ reviews on Judge.me for ProHealth’s NMN products are largely positive. Many users report increased energy, improved focus, and positive effects on their workouts. Some users mention enhanced endurance and stamina, making it suitable for physical activities. Users appreciate the convenience of the products, and they find them effective in countering age-related issues. While these reviews are generally favorable, it’s important to keep in mind that individual experiences may vary, and results may depend on factors like age, lifestyle, and overall health.
Pros
- Offers NMN in various forms
- Pharmaceutical-Grade Quality
- Additional Beneficial Ingredients
- Responsive Customer Service
- The supplements are reasonably priced
Cons
- Individual Variability
- Potential Side Effects
NMN Supplement #5 - Moleqlar
Uthever® NMN by MoleQlar shines as a prime choice for those seeking top-quality NMN products. Their exceptional purity level of over 99% is a testament to their commitment to delivering the best. The fact that it’s part of a significant clinical trial further demonstrates its effectiveness. Notably, it remains stable even under rigorous conditions, assuring customers of its unwavering quality.
While there’s a mention on their website of NMN not being intended for human consumption under German and European law, the availability of this product for personal use is a win for those looking to explore its potential benefits.
While price points might be somewhat higher compared to other powdered options, it’s important to remember that quality often comes with a cost. When you prioritize product excellence, this could be a justifiable investment.
In summary, Uthever® NMN sets a high standard in the world of NMN supplements, and MoleQlar provides a valuable gateway for individuals to access this premium product. It’s reassuring to see such quality options available for those looking to support their health and well-being.
What customers say about MoleQlar
Customers on Reviews.io have given mostly positive feedback about MoleQlar’s products and services. They appreciate the quality of the products and prompt delivery. Some customers noted that it was too early to comment on product effectiveness. While a few expressed concerns about the price and one customer mentioned a delivery delay, MoleQlar responded to this issue, explaining the shipping timeline. Overall, customers seem satisfied with MoleQlar’s offerings and customer service.
Pros
- Exceptional >99% purity
- Part of a major NMN clinical trial
- Rigorously tested for quality
- Multiple product variants available
Cons
- No measuring spoon included in the delivery
- Slightly higher prices compared to other options
- Legal Considerations
brands Comparison
| Product | Brand | Ingredients / Dosage per serving | Serving / Price |
|---|---|---|---|
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ß - Nicotinamide Mononucleotide (NMN) 250 mg Nicotinamide Adenine Dinucleotide (NAD+) 190 mg Nicotinamide Riboside (NR) 160 mg Niacin 125 mg |
Serving size: 2 Vegetarian capsules Servings per container: 45 Cost per serving: $1.88 |
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Longevir™ NMN (β-Nicotinamide mononucleotide) 250 mg |
Serving size: 2 HPCM vegan capsules Servings per container: 30 Cost per serving: €2 |
#3Uthever® PURE NMN(Non-liposomal Capsules) |
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β-nicotinamide mononucleotide (NMN) 1000 mg |
Serving size: 2 capsules Capsules in bottle: 366 Cost per serving: €2.57 |
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β-nicotinamide mononucleotide (NMN) 1000 mg |
Serving size: 2 capsules Servings per container: 30 Cost per serving: $3.83 |
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β-Nicotinamide mononucleotide (NMN)* with >99% certified purity 15 gram = 1x 15 g pouch |
Daily serving size: e.g., 1 g Net Weight: 30 g Price per Serving: 1.80 € |
FAQ - NMN (Nicotinamide Mononucleotide) and NAD+
1. What Is NMN (Nicotinamide Mononucleotide)?
NMN is a compound that serves as a precursor to nicotinamide adenine dinucleotide (NAD+), a critical molecule for cellular function. It is produced through the conversion of nicotinamide and ribose-containing nucleosides.
2. How Do NMN Supplements Raise NAD+ Levels?
NMN supplements increase NAD+ levels by acting as a precursor for NAD+ in the salvage pathway. This pathway is more efficient in NAD+ production compared to de novo synthesis. NMN is orally bioavailable and quickly absorbed into the bloodstream.
3. What Is NAD+?
Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme essential for cellular functions, including glycolysis, fatty acid metabolism, and the Krebs cycle. NAD+ plays a crucial role in redox reactions within cells.
4. How Is NAD+ Made?
NAD+ can be synthesized through various pathways, including de novo synthesis, Preiss-Handler pathway, and the salvage pathway. The salvage pathway, involving NMN conversion to NAD+, is a rapid and efficient method.
5. What Are the Cellular Health Benefits of NAD+?
NAD+ is crucial for various biochemical reactions, including glycolysis, fatty acid storage, and ATP production. It plays a role in maintaining cellular health and energy levels in the mitochondria and cytoplasm.
6. How Does NMN Supplementation Affect Cellular Function?
NMN supplementation enhances cellular respiration, allowing for the efficient conversion of macronutrients to ATP. This leads to increased energy production and improved cellular function, particularly in skeletal muscle.
7. How Does NMN Affect Longevity and Aging?
Aging is associated with decreased NAD+ levels, leading to age-related diseases. NMN supplements can increase NAD+ levels, potentially reversing age-associated gene expression and promoting healthy aging.
8. How Does NMN Affect Cerebral Blood Flow and Cognition?
NMN increases NAD+ levels, which promote neurovascular coupling and improve cerebral blood flow. This can lead to enhanced cognitive function, improved memory, and coordination.
9. How Does NMN Affect Cardiovascular Health?
NMN supplementation can reverse the NADH/NAD+ ratio imbalance, leading to improved heart health. It maintains pro-survival capabilities of cardiac cells and supports cardiac activity.
10. Can NMN Supplements Help with Neurological Disorders?
NMN supplements may benefit individuals with neurological disorders such as Alzheimer’s and Parkinson’s disease by improving mitochondrial function and reducing oxidative stress.
11. What Is the Difference Between NR and NMN Supplements?
Nicotinamide riboside (NR) is another precursor to NAD+ through the salvage pathway. NR requires additional steps to convert to NAD+, while NMN is one step away from NAD+. NMN supplements are more readily converted into NAD+.
12. Are NMN Supplements Safe?
Both animal and human studies have shown that NMN supplements are safe. In animal studies, adverse effects were minimal at lower doses, and clinical trials in humans demonstrated increased NAD+ levels without adverse effects on vital signs.
Science behind NMN and its potential benefits
How NMN can help you reclaim your vitality and enjoy a healthier life
NMN Benefits