Anxiety is a debilitating mental health condition that impacts countless individuals globally. From social anxiety to generalized anxiety disorder, the symptoms of anxiety can disrupt daily life and cause significant distress.
Fortunately, there are several treatment options available for individuals struggling with anxiety, including cognitive-behavioral therapy, meditation, medication, and natural remedies. However, a specific types of nootropics have emerged as an increasingly popular treatment option for anxiety due to their ability to enhance cognitive function and promote relaxation.
In this review, we have explored the Anxiolytics bundle from Cosmic Nootropics, a company that has successfully distributed several potent anxiolytic supplements from the ex-Soviet manufacturers. The bundle contains five prescription-free synthetic supplements that have been extensively studied and shown to have powerful anxiolytic and nootropic effects.
Our review has taken a rigorous approach to evaluating each of the compounds in the Anxiolytics bundle. We have analyzed the scientific research behind each compound and assessed their safety and efficacy. We have also provided guidance on dosage and usage (recommended by manufacturers) to help individuals safely and effectively use the supplements.
Our goal with this review is to provide an unbiased assessment of the Anxiolytics bundle from Cosmic Nootropics to help individuals struggling with anxiety make an informed decision about whether this supplements is right for them. With our in-depth analysis, we hope to provide a valuable resource for those seeking alternative treatment options for anxiety.
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Cosmic Nootropic Anxiolytics Bundle Review
anxiolytic vs benzodiazepine
Many countries have made significant contributions to the field of anxiolytics and mental health more broadly, including the United States and Russia.
The US is home to many of the world’s leading academic and research institutions in the field of mental health. The National Institute of Mental Health (NIMH) is a major contributor to research on anxiety and other mental health issues, and many of the most widely-used anti-anxiety medications, such as benzodiazepines and selective serotonin reuptake inhibitors (SSRIs), were developed in the US.
The Russian school of thought on anxiolytics has its roots in the Soviet era, where the government prioritized the development of anxiolytic drugs. While there are also researching alternative therapies, several drugs were developed during this time also, including Phenibut, Adaptol, and Picamilon which are still used today in some parts of the world as treatments for anxiety and other mental health conditions. In recent times, Mexidol and Afobazole also got attention.
How anxiolytics work?
Regulation of GABA
It is an inhibitory neurotransmitter that helps regulate anxiety levels in the brain. Certain synthetic nootropics, such as phenibut and picamilon, are believed to enhance GABA activity, which can result in decreased anxiety and increased relaxation. This effect can be especially helpful for those who struggle with generalized anxiety disorder or social anxiety disorder.
Regulation of serotonin
It is a neurotransmitter that plays a crucial role in regulating mood and anxiety. Anxiolytics have been shown to enhance serotonin activity, leading to decreased anxiety and improved mood. This effect can be particularly beneficial for those with depression and anxiety disorders.
It is a stress hormone that is released in response to anxiety and stress. Natural substances like ashwagandha and rhodiola rosea have been shown to regulate cortisol levels, reducing the body’s response to stress and anxiety. The compounds in this Anxiolytics bundle can do the same, only faster than natural remedies. This effect can be especially helpful for individuals dealing with chronic stress or anxiety disorders.
Enhance cognitive function
While racetams, for example, are known to improve memory and cognitive function, which can help those with anxiety disorders feel more in control of their thoughts and behaviors – anxiolytics can do more for anxiety and stress support while secondary improving cognitive function too.
Cosmic Nootropic anxiolytics are prescription free and are distributed by branded manufacturers so we are reviewing them in this post. Stay with us.
Phenibut and anxiolytics
The Soviet era of anxiolytics is a fascinating chapter in the history of medicine. During this time, Soviet scientists were at the forefront of developing new anxiolytics that could alleviate the symptoms of anxiety without causing unwanted side effects.
One of the most notable anxiolytics to come out of the Soviet era was Phenibut, a derivative of the neurotransmitter GABA that was first synthesized in the 1960s. Phenibut was developed as a treatment for anxiety and other neurological disorders and quickly gained popularity due to its effectiveness and low side-effect profile.
Phenibut was widely used in the Soviet Union and its satellite states, where it was considered a safe and effective treatment for anxiety and other conditions. However, following the collapse of the Soviet Union, Phenibut fell out of favor and was largely forgotten outside of Russia and its neighboring countries.
Today, Phenibut is once again gaining popularity as a nootropic and anxiolytic, particularly among individuals looking for an alternative to traditional anxiolytic drugs like Benzodiazepines. In Russia, Phenibut is still used as a prescription medication for anxiety and other conditions, and there are some Russian brands that manufacture and distribute Phenibut supplements worldwide.
Despite its popularity, Phenibut is not without its risks. Long-term use of the substance has been associated with tolerance, dependence, and withdrawal symptoms, and there have been reports of serious adverse effects, particularly when the substance is used in high doses or in combination with other drugs.
As with any anxiolytic or nootropic, it is important to use Phenibut only under the guidance of a healthcare professional and to be aware of the potential risks and side effects associated with its use. While the Soviet era of anxiolytics was a fascinating time in the history of medicine, it is important to approach these substances with caution and to prioritize safety and health above all else.
Why healthy people take Anxiolytics?
Anxiolytics have been found to have several benefits that healthy people can explore. Here are some of the key benefits:
Targeted action: Anxiolytics are designed to target specific areas of the brain that are involved in regulating anxiety and stress, providing a more focused and effective approach to anxiety relief.
Potency: Anxiolytic nootropics can be more potent and effective than natural remedies, providing a higher level of anxiety relief for those with severe or chronic anxiety.
Consistency: Synthetic anxiolytics can provide a more consistent and reliable effect than natural remedies, as they are formulated to deliver a specific dose of the active ingredient.
Safety: Anxiolytics are developed through rigorous scientific research and testing, ensuring their safety and effectiveness when used appropriately.
Fewer side effects: Synthetic anxiolytics are often associated with fewer side effects compared to traditional anxiety medications, making them a more appealing option for those who want to avoid sedation or other unwanted side effects.
Cognitive enhancement: Some anxiolytics are also known to enhance cognitive function and improve memory, providing additional benefits beyond anxiety relief.
Moreover, more research is needed to fully understand the long-term effects of using anxiolytic nootropics for anxiety relief.
Anxiolytics Bundle testing
The Cosmic Nootropic Anxiolytics Bundle is a combination of synthetic anxiolytics from the ex-Soviet school of thought that is designed to help relieve anxiety and promote relaxation.
We reviewed them here at Nootropicblend.com with special care, taking them individually or stacked with one another, just to see over and over again its potency and effectiveness in many social situations.
Taking these anxiolytics even in smaller doses brought us excellent and quick results. Something we’ve not usually seen with herbal or natural products.
No matter how enthusiastic we are, it should be noted that these products are not or should not be for daily use, but as a means on certain special days when social situations require it.
Anxiolytics included in the Anxiolytics bundle and their benefits
Phenibut, Mexidol, Adaptol, Mebicar, Picamilon, and Afobazole are all types of supplements known for their anxiolytic properties.
- Phenibut – GABA receptor agonist that has been shown to reduce anxiety and promote relaxation, while also enhancing cognitive performance in some individuals. However, it can be habit-forming and may cause withdrawal symptoms if taken for an extended period or in high doses.
- Mexidol – also known as Emoxypine, is a compound that has been shown to have antioxidant, anxiolytic, and nootropic properties. It works by reducing oxidative stress in the brain and improving blood flow, which can help improve cognitive function and reduce anxiety.
- Adaptol – also known as Mebicar, is a non-benzodiazepine anxiolytic that has been shown to reduce anxiety and improve cognitive function. It works by increasing the production of serotonin and dopamine, two neurotransmitters that play a role in regulating mood.
- Picamilon – a compound that combines niacin and GABA, allowing it to cross the blood-brain barrier more easily. It has been shown to reduce anxiety, improve cognitive function, and even increase cerebral blood flow in some individuals.
- Afobazole – a non-benzodiazepine anxiolytic that has been shown to reduce anxiety and improve cognitive function without causing sedation or other negative side effects. It works by modulating the activity of the GABA receptor and regulating the release of stress hormones.
There are other supplements that have similar anxiolytic properties, including L-theanine, ashwagandha, valerian root, kava, and passionflower. Read about them in our post 30+ best nootropics for mood & stress support.
Potential side effects of using anxiolytics
Phenibut, for example, can cause dizziness, drowsiness, nausea, and headaches. It can also lead to dependence and withdrawal symptoms if used in high doses or for prolonged periods. Mexidol may cause allergic reactions, as well as digestive and neurological side effects like nausea, headache, and dizziness. Adaptol is generally well-tolerated but may cause mild side effects such as stomach upset, drowsiness, or dry mouth.
Picamilon has been associated with blood pressure changes and may cause headaches, dizziness, or nausea. Afobazole is generally well-tolerated but may cause digestive symptoms like upset stomach or diarrhea.
Please, note this table by Cosmic Nootropic and follow especially dosage instructions and days of use to stay in the safe zone of using anxiolytics:
Pros and cons
Anxiolytics bundle is an assortment of the best Russian anxiolytics packed in an attractive sample format for you to try and decide which ones correspond with your biochemistry in a safe and efficient manner.
It is important to note that the effectiveness of these anxiolytics can vary greatly depending on the individual and their specific needs. Additionally, potential side effects and interactions with other medications should be carefully considered before use. It is also important to only purchase anxiolytics from reputable sources and to follow recommended dosages.
Overall, while the Cosmic Nootropic Anxiolytics Bundle may offer potential benefits for those looking to reduce anxiety, it is important to approach these substances with caution and thoroughly research their potential risks and benefits.
- Owen et al (2016) Phenibut (4-amino-3-phenyl-butyric acid): Availability, prevalence of use, desired effects and acute toxicity https://www.ncbi.nlm.nih.gov/pubmed/26693960
- Volotova et al (2016) Neuroprotective action of phenibut and neuroglutam in experimental cerebral ischemia on the background of altered immunoreactivity https://www.ncbi.nlm.nih.gov/pubmed/29949699
- Vavers et al (2016) The neuroprotective effects of R-phenibut after focal cerebral ischemia https://www.ncbi.nlm.nih.gov/pubmed/26621244
- Androfagina et al (2015) Mexidol in the rehabilitation of patients in the acute ischemic stroke https://www.ncbi.nlm.nih.gov/pubmed/26978645
- Gromova et al (2018) Experience with mexidol in neurological practice https://www.ncbi.nlm.nih.gov/pubmed/30499505
- Shamrey et al (2020) [Possibilities of using Mexidol in the complex therapy of mental disorders] https://pubmed.ncbi.nlm.nih.gov/32621483/
- Voronina et al (2022) [The role of oxidative stress in hemorrhagic stroke and restorative effects of Mexidol] https://pubmed.ncbi.nlm.nih.gov/36036146/
- V Vorob’eva, V Repina (2016) An open comparative observational study of the efficacy and safety of adaptol in anxiety-asthenic disorders in patients with chronic cerebral ischemia https://www.ncbi.nlm.nih.gov/pubmed/27070467
- J Zhitkova, D Hasanova (2017) An experience of using mebicar in patients with autonomic dysfunction associated with anxiety disorder https://www.ncbi.nlm.nih.gov/pubmed/29265088
- Kotova et al (2022) [Sleep disorders in post-COVID syndrome – a problem of psychiatry or neurology?] https://pubmed.ncbi.nlm.nih.gov/35759562/
- I Sapegin, A Beketov (1993) The effect of pikamilon and fenibut on the blood supply of the brain at rest and under gravitational exposures https://www.ncbi.nlm.nih.gov/pubmed/8324468
- Silkina et al (2005) Gabaergic mechanism of cerebrovascular and neuroprotective effects of afobazole and picamilon https://www.ncbi.nlm.nih.gov/pubmed/15786959
- Likhodeev et al (2009) Effects of aminalon, fenibut, and picamilon on the typological parameters of cerebral hemodynamics in swimmers with dysadaptation syndrome https://www.ncbi.nlm.nih.gov/pubmed/19803364
- Seredenin et al (2013) On the mechanism of anti-ischemic effects of afobazole https://www.ncbi.nlm.nih.gov/pubmed/24288760
- Kadnikov et al (2015) Cytoprotective Effect of Afobazole and Its Main Metabolite M-11 https://www.ncbi.nlm.nih.gov/pubmed/26033588
- Kryzhanovkii et al (2018) On the Mechanism of the Cardioprotective Action of σ1 Receptor Agonist Anxiolytic Fabomotizole Hydrochloride (Afobazole) https://www.ncbi.nlm.nih.gov/pubmed/30225699
- Kryzhanovskii et (2021) Angiogenic Effects of Anxiolytic Fabomotizole https://pubmed.ncbi.nlm.nih.gov/33895918/