The 4 Healing Cat’s Claw Benefits | One Is a Nootropic

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South America’s rich biodiversity, fostered by unique climatic conditions and the vast Amazonian rainforest, has given rise to numerous plants with exceptional nutritional and medicinal properties, such as Maca and Camu Camu. Among these natural treasures is Cat’s Claw (Uncaria tomentosa), a woody vine indigenous to the Amazon rainforest and tropical areas of South and Central America. In this article, we will explore the numerous Cat’s Claw benefits, ranging from its immune-boosting properties to its potential role in cognitive health and cancer support.

Table of Contents

What is cat's claw herb?

Woody-wine Cat's Claw benefits

Known scientifically as Uncaria tomentosa and locally as Uña de Gato or Savéntaro, Cat’s Claw earned its name from its distinctive claw-shaped thorns. Indigenous tribes have utilized this plant for centuries, recognizing its diverse health benefits, ranging from anti-inflammatory effects to immune system support and cognitive enhancement.

Often called the “Peruvian life-giving vine,” Cat’s Claw is revered as a sacred plant by communities such as the Asháninka, Aguaruna, and Shipibo. These groups traditionally prepare a decoction from the bark, consumed as a tea to address various ailments including inflammation, allergies, and arthritis.

Chopped Bark of Cat's Claw Uncaria Tomentosa
Chopped Bark of Cat’s Claw (Uncaria Tomentosa)

Bioactive substances in cat’s claw

The therapeutic potential of Cat’s Claw stems from its rich array of bioactive compounds:

  1. Polyphenols: Potent antioxidants that neutralize free radicals and reduce oxidative stress.
  2. Glycosides: Modulate immune responses and provide anti-inflammatory effects.
  3. Sterols: Found in the inner bark, these support cardiovascular health and help maintain cholesterol levels.
  4. Oxindole Alkaloids: The most significant compounds, particularly pentacyclic oxindole alkaloids (POAs), which offer:
    • Enhanced immune function by stimulating phagocytosis and boosting white blood cell activity
    • Anti-inflammatory effects
    • Potential cognitive health benefits, including memory support

It’s worth noting that while several herbs are marketed as “Cat’s Claw,” Uncaria tomentosa is the most valued species due to its abundance of active substances. The inner bark and root contain at least 30 bioactive compounds, including 17 alkaloids known for their nootropic and neuroprotective benefits.

High-quality Cat’s Claw supplements are typically standardized to ensure a specific concentration of oxindole alkaloids, providing consistent therapeutic effects and a reliable measure for consumers seeking effective formulations.

The synergy of these bioactive compounds, particularly the oxindole alkaloids, underpins Cat’s Claw’s extensive health benefits, making it a subject of growing interest in natural medicine and scientific research.

 

Anti-Inflammatory Benefits

Cat’s Claw has gained recognition for its potent anti-inflammatory properties, supported by scientific research:

  • Mechanism of Action: Studies show that Cat’s Claw inhibits the activation of NF-κB, a transcription factor crucial in regulating immune responses and inflammation. By blocking NF-κB, it reduces the production of tumor necrosis factor alpha (TNFα), effectively “putting out the fire” of inflammation, making Cat’s Claw particularly effective for conditions like arthritis, osteoarthritis, and rheumatoid arthritis.
  • Clinical Evidence:
    • A 2007 study published in BMC Complementary Medicine and Therapies found that a combination of Cat’s Claw and Maca reduced pain and stiffness in osteoarthritis patients, with less reliance on painkillers compared to a glucosamine sulfate group. This suggests the combination is a valuable natural aid for joint health.
    • A 2002 randomized double-blind trial in The Journal of Rheumatology demonstrated a significant reduction in joint pain for rheumatoid arthritis patients taking Cat’s Claw extract over 24 weeks. This study supports its strong anti-inflammatory effects. 

These studies underscore Cat’s Claw’s potential as an effective natural anti-inflammatory treatment, particularly for joint-related conditions.

The 20 Best Immune System Supplements

Antiviral Properties and Immune Support

Cat’s Claw shows promise in boosting immunity and combating viral infections:

  • Viral Inhibition: In vitro studies have shown Cat’s Claw extracts can inhibit the replication of herpes simplex virus type 1 (HSV-1). It typically causes infections on the lips, mouth, and face. This suggests a potential antiviral benefit, though human studies are needed for more concrete conclusions.
  • Immune Response Enhancement: A 2001 study in Phytomedicine found that Cat’s Claw extract improved the lymphocyte-to-neutrophil ratio and maintained higher antibody levels in response to the pneumococcal vaccine. This study indicates that Cat’s Claw may enhance the effectiveness of the pneumococcal vaccine.
  • COVID-19 Potential: Recent in silico research identified several pharmacologically active substances in Cat’s Claw that might prevent the attachment of the COVID-19 virus to host cells. While this is a preliminary computer-based analysis, it highlights Cat’s Claw’s potential as a complementary approach in the fight against COVID-19. 

While these findings are promising, further clinical research is needed to confirm Cat’s Claw’s antiviral and immune-boosting effects in humans.

Cognitive Enhancement

Traditional use of Cat’s Claw for cognitive function is increasingly supported by scientific research:

  • Memory Improvement: Studies indicate Cat’s Claw can enhance memory, particularly short-term memory. The alkaloid Rhynchophylline (Rhy) is believed to play a key role in promoting long-term potentiation, a key mechanism in learning and memory.
  • Alzheimer’s Disease: A 2019 study in Scientific Reports showed Cat’s Claw extract reduced amyloid beta plaques and neurofibrillary tangles in mice with Alzheimer’s, suggesting that Cat’s Claw may help mitigate some of the negative changes associated with brain aging and Alzheimer’s disease.
  • Neuroprotection: Cat’s Claw influences neuroplasticity and neuroprotection by increasing Brain-Derived Neurotrophic Factor (BDNF) expression and activating the PI3K/Akt/mTOR signaling pathway, crucial for long-term potentiation and memory improvement..

The extract C-Med-100® (AC-11®) from Uncaria tomentosa is particularly noted for its cognitive benefits and is included in commercial nootropic supplements like NooCube and Alpha Brain.

Check the Cat's Claw benefits in the popular Alpha Brain

Cancer Support

Cat’s Claw shows potential in cancer prevention and as a supportive therapy:

  • Preventive Effects: Research suggests Cat’s Claw may help prevent tumor cell proliferation. Its bioactive compounds are thought to contribute to this effect, potentially making it a valuable addition to cancer prevention strategies.
  • Chemotherapy Support: A 2012 study in Evidence-Based Complementary and Alternative Medicine found that Cat’s Claw extract (300 mg daily) reduced neutropenia incidence in breast cancer patients undergoing chemotherapy. This study indicates its potential as an effective supportive therapy for breast cancer.
  • Quality of Life: A 2015 study in the Journal of Integrative and Complementary Medicine reported improved quality of life and reduced fatigue in terminal cancer patients taking Cat’s Claw extract (100 mg three times daily). This study suggests that Cat’s Claw may provide natural support in managing cancer-related symptoms. However, it’s important to note that Cat’s Claw should complement, not replace, standard cancer treatments.

While promising, it’s crucial to note that Cat’s Claw should complement, not replace, standard cancer treatments. Further research is needed to fully understand its therapeutic potential in cancer care.

Potential Side Effects

While generally considered safe, it’s important to be aware of potential side effects:

  1. Digestive issues: Mild discomfort such as nausea, diarrhea, or stomach cramps may occur.
  2. Allergic reactions: Though rare, symptoms may include itching, rash, hives, or difficulty breathing.
  3. Blood pressure and clotting effects: May lower blood pressure and affect blood clotting.
  4. Immune system effects: Stimulation of the immune system may be inappropriate for those with autoimmune conditions.
  5. Drug interactions: Possible interactions with certain medications, including immunosuppressants, chemotherapy drugs, and antihypertensives.

It’s always recommended to consult a healthcare professional before starting any new supplement, especially if you have pre-existing health conditions or are taking other medications.

Types of Cat's Claw supplements

When selecting a Cat’s Claw supplement, consider the form and concentration of active ingredients:

  1. Powdered Inner Bark Capsules: Usually the most accessible and affordable option. Often contain 1,000 mg of powdered inner bark.
  2. Standardized Extracts: Typically standardized to 1.5% to 3% oxindole alkaloids and 15% phenols. Ensure consistent potency and quality.
  3. AC-11® (C-MED-100®): A patented hot-water extract standardized to 8% carboxy alkyl esters. Known for potential benefits in DNA repair and cognitive health.
  4. Savéntaro® POA Cat’s Claw: A specialized form standardized to 1.3% pentacyclic oxindole alkaloids (POA) and purified from tetracyclic oxindole alkaloids (TOA).

For those seeking a reliable cat’s claw supplement, we have tried and recommend HealthyCell AC-11®, which we found to be of high quality. 

Healthycell AC11 Front
HealthyCell AC-11 nootropic supplement - click to learn more
Healthycell AC11 Capsules
Healthycell AC11 Capsules - click to learn more

Conclusion: The Promise and Potential of Cat's Claw

Cat’s Claw (Uncaria tomentosa) stands out as a powerful natural remedy with a rich history and growing scientific backing. Its diverse array of benefits – from reducing inflammation and bolstering immune function to enhancing cognitive performance – positions it as a valuable asset in the realm of natural health solutions.

The inclusion of Cat’s Claw in popular nootropic formulations like Alpha Brain and NooCube underscores its recognized potential for cognitive enhancement. This trend reflects a broader shift towards natural ingredients in the pursuit of mental clarity and improved brain function.

However, the power of Cat’s Claw comes with a responsibility for informed use. While its benefits are promising, individual responses can vary, and interactions with certain medications are possible. Therefore, personalized guidance from healthcare professionals is crucial, especially for those with pre-existing health conditions or on medication regimens.

As research continues to unveil the full spectrum of Cat’s Claw’s capabilities, its role in holistic health practices is likely to expand. By approaching its use with mindfulness and expert advice, individuals can harness the potential of this Amazonian wonder to support their health and cognitive well-being.

Ultimately, Cat’s Claw exemplifies the intricate balance between traditional wisdom and modern science in our quest for natural health solutions. As we continue to explore its benefits, Cat’s Claw may well become a cornerstone in the future of integrative medicine and cognitive enhancement strategies.

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