Piracetam Review: A Fresh Perspective on the Classic Nootropic Branded as Nootropil

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PIRACETAM (Nootropil ®)
NOOTROPIL front sq

Welcome to our in-depth review of Piracetam, a legendary nootropic known for its potential cognitive-enhancing properties. If you’re curious about nootropics and their impact on cognitive function, you’ve come to the right place. In this blog post, we will take a closer look at Piracetam, exploring its fascinating history, mechanisms of action, and the scientific evidence supporting its reputed benefits. As one of the earliest and most well-known nootropics, Piracetam has captured the attention of researchers and individuals seeking to optimize their mental performance. Join us as we delve into the latest research and studies conducted on this remarkable compound, and uncover the potential it holds for memory improvement, focus, and brain health. Also, find our experience from one of the best places to buy Piracetam (Nootropil): Cosmic Nootropic.

Product Brand: PIRACETAM (Nootropil®)

Editor's Rating:

Benefits and effects


  • Form: pills 1200 mg / pills 800 mg / ampoules 5 ml, 200 mg/ml

  • Manufacturer: UCB Pharma (Belgium)

  • GMP quality

  • Pharmacological action: Nootropic, anti-hypoxic, cerebroprotective

  • Original pharmaceutical product that passed 3 stages of clinical trials

  • 2–5 days US delivery for $6.90; 4–8 weeks international delivery for $40

  • Shelf life: 3 years

  • Storage conditions: Store in a dry dark place at temperatures no higher than 30°C.

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The Foundation of Piracetam

Piracetam as sleep aid paperIn the 1960s, Romanian psychologist and chemist Corneliu E. Giurgea embarked on a quest to develop a novel compound that could enhance cognitive function without the typical side effects of stimulants. His visionary work paved the way for a new class of substances known as nootropics, derived from the Greek words “nous” (mind) and “tropos” (turning). The nootropic concept emphasized the idea of compounds that could “turn the mind” toward improved cognitive abilities, memory, and learning.

Giurgea and his team synthesized Piracetam in 1964 as the first-ever compound designed under the nootropic concept. The breakthrough came as a surprise when they discovered Piracetam’s profound effects on learning and memory in animal studies. This unexpected discovery marked the birth of the first true nootropic, setting the stage for further investigations into cognitive enhancers.

In the subsequent years, extensive research followed, exploring Piracetam’s effects on various aspects of cognitive function. Researchers observed its ability to improve memory retention, enhance learning capacity, and boost focus and concentration. Unlike traditional stimulants, Piracetam did not cause sedation, addiction, or severe side effects, making it a groundbreaking development in the field of cognitive enhancement.

As the foundation of nootropics, Piracetam’s mechanisms of action were the subject of intense scientific scrutiny. While the exact molecular pathways remain partially elusive, research indicated that Piracetam modulates neurotransmitter systems, particularly acetylcholine and glutamate. These actions are thought to contribute to:

  • enhanced synaptic plasticity
  • neuroplasticity
  • improved cognitive performance

Piracetam’s significance extends far beyond its initial discovery. Its impact on cognitive enhancement research has paved the way for the exploration of other nootropics and cognitive enhancers. However, as with any cognitive-enhancing substance, ethical considerations surrounding responsible use, potential long-term effects, and individual variations in response remain essential aspects to be addressed.


A brief overview of Piracetam’s benefits and traditional use

Piracetam is one of the earliest and most well-known nootropics, commonly used for its purported cognitive-enhancing effects. Here are some of the better-known facts from the scientific papers collected over the years, as well as anecdotal use of this legendary smart drug. Also, what is its legal status nowadays?

  1. Cognitive Enhancement: Piracetam is often referred to as a cognitive enhancer due to its potential to improve cognitive functions such as memory, learning, and focus. Its mode of action is not fully understood, but it is believed to modulate neurotransmitter systems in the brain.

  2. Neurotransmitter Modulation: Piracetam’s influence on neurotransmitters, particularly acetylcholine and glutamate, is considered central to its cognitive effects. It is thought to enhance cholinergic transmission and increase the release of glutamate, leading to improved synaptic plasticity and cognitive function.

  3. Memory Improvement: Several studies and user reports have suggested that Piracetam may have a positive impact on memory, particularly in tasks related to memory retention and recall. It is often used by students and individuals seeking cognitive enhancement.

  4. Neuroprotective Properties: There is some evidence suggesting that Piracetam may have neuroprotective effects, potentially shielding the brain from oxidative stress and reducing neuroinflammation. These properties have led to research into its potential therapeutic use in neurodegenerative diseases.

  5. Safe and Well-Tolerated: Piracetam is generally considered safe and well-tolerated when used within recommended dosage guidelines. Reported side effects are mild and infrequent, with most users experiencing no adverse effects.

  6. Limited Long-Term Studies: While Piracetam has been widely used for several decades, comprehensive long-term studies on its effects are limited. More research is needed to fully understand its long-term safety and efficacy.

  7. Individual Variations: Responses to Piracetam can vary among individuals, with some experiencing more pronounced cognitive benefits than others. Factors such as genetics, lifestyle, and brain chemistry may contribute to these individual differences.

  8. Legal Status Today: While Piracetam is prescribed in some European countries for cognitive impairment and dementia, its efficacy remains questionable. In the United States, Piracetam has no FDA-approved use and is not permitted to be sold as a dietary supplement, but its availability remains due to limited enforcement. The research found that several cognitive enhancement supplements contained Piracetam at dosages exceeding pharmaceutical levels, raising concerns about potential adverse effects, especially in elderly consumers with renal insufficiency. Until better regulation is established, clinicians should caution patients about the risks associated with such supplements.

It’s essential to note that research on nootropics, including Piracetam, is continually evolving. Always consult with a healthcare professional before starting any new supplement or nootropic regimen.

Piracetam tablets

My experience using Nootropil

During my experimentation with Nootropil, I found the effects to be quite subtle and inconsistent. At times, I experienced improved focus and concentration, making tasks seem easier to accomplish. However, there were also occasions when I didn’t notice any significant cognitive enhancements. I experimented with different dosages and tried taking it with choline, as it is suggested, to counter potential side effects like headaches and dizziness. While this seemed to mitigate some of the adverse reactions, the overall cognitive benefits remained relatively modest.

I also decided to stack it with some natural nootropics to see if it could enhance the overall cognitive enhancement experience.

The nootropics I mostly stack Piracetam with are:

  • Lyon’s Mane
  • Bacopa
  • Rhodiola
  • CDP-Choline
  • L-theanine
  • Caffeine

I’m pleased to report that the combination had a notably positive impact on my cognitive function, and I experienced improved focus, enhanced memory, and heightened mental clarity. What was even more remarkable was that I didn’t experience any adverse effects while using the stacks. But, I also don’t encourage everyone to experiment with Piracetam and too many other nootropics. Especially not the beginners. It might be an edge experience for some users, and if they try it, it is better to start with smaller doses of Piracetam first, in the case of Nootropil with half a tablet. You can also safely use some of these premade nootropic stacks for similar results.

Nevertheless, the addition of Nootropil seemed to amplify the effects of the other nootropics and natural blends, resulting in a more potent and well-rounded cognitive enhancement experience. Also, read about our Cosmic Nootropic review for additional information about effective Piracetam-like nootropics.

While using these combinations, I noticed a substantial boost in productivity during work sessions. My logic-based thinking was notably sharper, and I could breeze through analytical tasks with ease. Additionally, my ability to retain information and recall details improved, making learning more efficient and effective.

One aspect that pleasantly surprised me was the positive impact on my mood and motivation. I felt more energized and enthusiastic, which further fueled my desire to achieve my goals and pursue new challenges.


Piracetam and novel research

Piracetam, the pioneering nootropic, continues to captivate researchers as novel studies explore its potential effects on gene expression, the gut-brain axis, and synergies with other cognitive enhancers. This evolving research aims to unlock the intricate molecular mechanisms behind Piracetam’s cognitive benefits and offers exciting possibilities for personalized cognitive enhancement strategies.


Epigenetic Effects of Piracetam

The emerging field of epigenetics has sparked interest in understanding the potential epigenetic effects of Piracetam on cognitive function. Epigenetics refers to changes in gene expression that are not caused by alterations in the DNA sequence itself but rather modifications to the DNA, such as DNA methylation, and histones, which can affect gene activity. 

This study aims to investigate whether Piracetam has any epigenetic impact on gene expression related to cognitive function, specifically exploring its potential to alter DNA methylation or histone modification patterns in brain cells. By uncovering Piracetam’s epigenetic effects, researchers hope to gain deeper insights into the mechanisms underlying its cognitive-enhancing properties and explore novel therapeutic possibilities for enhancing cognitive function.


Gut-Brain Axis and Piracetam

The gut-brain axis is a bidirectional communication system between the gut and the brain, which has been recognized for its significant influence on various aspects of health, including cognitive function. This study aims to explore the potential impact of Piracetam on the gut microbiome and its implications for cognitive function. Researchers will investigate whether Piracetam administration has any discernible effects on the composition and diversity of gut microbes. 

Furthermore, the study aims to determine if gut-brain communication plays a role in Piracetam’s cognitive effects, potentially shedding light on how the gut microbiota may influence brain health and cognitive performance. Understanding the relationship between Piracetam, the gut microbiome, and cognitive function may open new avenues for cognitive enhancement and provide insights into the multifaceted mechanisms underlying Piracetam’s cognitive-enhancing properties.


Piracetam and Sleep

Understanding the potential impact of Piracetam on sleep is crucial, as quality sleep is essential for overall cognitive function and well-being. This study aims to examine the relationship between Piracetam use and sleep quality, specifically investigating its effects on sleep architecture, sleep duration, and sleep-related cognitive processes. Researchers will conduct controlled trials and gather data on participants’ sleep patterns and cognitive performance before and after Piracetam administration. 

By analyzing sleep architecture and duration, the study seeks to determine whether Piracetam has any influence on the different stages of sleep. Additionally, researchers will assess any potential effects on sleep-related cognitive processes, such as memory consolidation and cognitive functioning upon waking. A comprehensive understanding of the impact of Piracetam on sleep could provide valuable insights into its overall effects on cognitive performance and help users optimize their cognitive enhancement strategies while considering the crucial aspect of sleep hygiene.


Neurotransmitter Receptor Subtypes

Neurotransmitter receptor subtypes play a vital role in mediating the effects of neurotransmitters in the brain. These receptors are specialized proteins found on the surface of nerve cells and act as “locks” that specific neurotransmitters can bind to, triggering specific cellular responses. Different neurotransmitter receptor subtypes exist for various neurotransmitters, allowing for precise signaling and communication between neurons. 

Understanding the specific receptor subtypes influenced by nootropics like Piracetam is crucial for unraveling their cognitive-enhancing mechanisms and potential interactions with other compounds. By identifying the receptor subtypes involved, researchers can gain insights into how Piracetam modulates neurotransmitter systems, thereby optimizing its cognitive effects and paving the way for the development of more targeted and effective cognitive enhancers.


Neuroprotective Effects in Neurodegenerative Diseases

The investigation of Piracetam’s potential neuroprotective effects in neurodegenerative diseases has garnered significant attention in the scientific community. Neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, involve the progressive loss of neurons and cognitive decline. Preclinical studies on Piracetam have shown promising results, suggesting that it may exert protective effects on neurons, counteract oxidative stress, and reduce neuroinflammation

These properties have sparked interest in evaluating Piracetam’s therapeutic potential as a supportive treatment for neurodegenerative conditions. While further research and clinical trials are needed to establish its efficacy definitively, the exploration of Piracetam as a neuroprotective agent holds hope for improving the quality of life and cognitive function in individuals affected by neurodegenerative diseases.


Personalized Cognitive Enhancement

Personalized cognitive enhancement is an evolving approach that recognizes the uniqueness of individuals and tailors cognitive enhancement strategies based on their specific needs, goals, and biological makeup. Understanding that each person’s cognitive profile is different, personalized cognitive enhancement aims to optimize brain function through targeted interventions. This approach may involve using various cognitive enhancers, including nootropics like Piracetam, as well as lifestyle modifications, cognitive training, and other interventions. 

By taking into account factors such as genetics, brain chemistry, lifestyle, and individual goals, personalized cognitive enhancement seeks to create tailored regimens that maximize cognitive performance while considering safety and ethical considerations. As research in this field continues, the potential for personalized cognitive enhancement to revolutionize how we approach brain health and optimize cognitive abilities is promising.


Piracetam’s Influence on Creativity

The influence of Piracetam on creativity is a subject of interest and exploration among users and researchers. While scientific studies specifically examining its effects on creativity are limited, anecdotal reports suggest that some individuals experience enhanced creativity when using Piracetam. Users have reported improved divergent thinking, the ability to generate novel ideas, and enhanced problem-solving skills.

Piracetam’s potential impact on neuroplasticity and neurotransmitter systems, such as acetylcholine and glutamate, may contribute to these cognitive enhancements. However, it is important to recognize that the relationship between Piracetam and creativity may vary among individuals, and additional research is needed to establish a definitive link. As with any cognitive enhancer, responsible use, individual differences, and potential risks should be considered when exploring Piracetam’s influence on creativity.


Impact of Piracetam on Brain Connectivity

The impact of Piracetam on brain connectivity has been an area of interest in cognitive research. While the specific effects on brain connectivity are not fully understood, some studies have suggested that Piracetam might influence neural networks and communication within the brain. By potentially enhancing synaptic plasticity and modulating neurotransmitter systems, Piracetam could have implications for the organization and strength of neural connections. 

However, research in this area is still in its early stages, and further studies, particularly using advanced neuroimaging techniques like functional MRI (fMRI) or diffusion tensor imaging (DTI), are needed to provide a more comprehensive understanding of Piracetam’s effects on brain connectivity. Such insights may contribute to a deeper understanding of how Piracetam impacts cognitive function and its potential as a cognitive enhancer.


Cognitive Enhancement and Neuroplasticity in Aging

Research has explored how cognitive enhancement interventions, including nootropics like Piracetam, may promote neuroplasticity and cognitive function in aging populations. These interventions aim to support and enhance cognitive abilities by potentially influencing neurotransmitter systems and neural connectivity.

While preliminary findings suggest that cognitive enhancement strategies may have positive effects on neuroplasticity and cognitive function in older adults, more extensive research is needed to establish their efficacy definitively. Additionally, it is essential to approach cognitive enhancement interventions with caution and under expert guidance, as individual responses and potential risks may vary.

Piracetam dosage

Typical Piracetam dosages for cognitive enhancement ranged from 1,200 mg to 4,800 mg per day, divided into two to three doses.

However, it is important to note that individual responses to Piracetam may differ, and some individuals may require lower or higher doses to achieve desired effects. Starting with a lower dosage and gradually increasing it, if necessary, is often recommended to assess individual tolerance and response.

It’s essential to prioritize safety when using any nootropic, including Piracetam. Avoid exceeding the recommended dosage, as excessive intake may lead to adverse effects or diminish the potential cognitive benefits. 

As with all supplements and nootropics, responsible use, proper dosage, and expert guidance are crucial to ensure a safe and beneficial cognitive enhancement experience.

Combining Piracetam with Other Nootropics

Research on specific Piracetam stacks with other nootropics was limited, some potential combinations were suggested anecdotally by users and nootropic enthusiasts. However, it is important to remember that individual responses can vary, and using any stack should be done with caution and under the guidance of a healthcare professional. Here are some potential stacks that were reported anecdotally:

Piracetam and Choline Source:

Piracetam is believed to increase the demand for acetylcholine, a neurotransmitter crucial for memory and learning. Combining Piracetam with a choline source like Alpha-GPC or CDP-choline may help support acetylcholine levels and prevent choline depletion.

Piracetam and Aniracetam:

Aniracetam is another racetam nootropic with a different mechanism of action compared to Piracetam. Combining the two may lead to a synergistic effect, potentially enhancing cognitive performance and memory.

Piracetam, Alpha-GPC, and L-Theanine:

This stack combines Piracetam and Alpha-GPC to support acetylcholine levels, along with L-Theanine to promote relaxation and reduce potential excitability.

Piracetam and Noopept:

Noopept is a peptide-based nootropic that some users reported combining with Piracetam to potentially amplify cognitive effects.

Piracetam, Lion’s Mane Mushroom, and Bacopa Monnieri:

Some users combine Piracetam with natural nootropics like Lion’s Mane Mushroom and Bacopa Monnieri to potentially enhance memory and cognitive function.

Piracetam and Rhodiola Rosea:

Rhodiola Rosea is an adaptogenic herb that may help reduce stress and fatigue. Combining it with Piracetam could potentially support cognitive function during stressful periods.

Piracetam and Omega-3 Fatty Acids:

Omega-3 fatty acids have been linked to brain health and cognitive function. Some users combine Piracetam with omega-3 supplements for potential cognitive benefits.

Piracetam and Modafinil (Off-label use, not recommended without medical supervision):

Some individuals reported combining Piracetam with modafinil, a wakefulness-promoting agent, to potentially enhance focus and productivity. However, this combination should not be attempted without medical supervision due to potential safety concerns. There are simply better stacks to explore.

It is important to note that these potential stacks were based on anecdotal reports and individual experiences. The safety and efficacy of these combinations were not rigorously studied or supported by conclusive scientific evidence. Read more about stacking nootropics aand learn about other racetams and their benefits.

Piracetam (Nootropil) review conclusion

Piracetam review


In conclusion, Piracetam, the original nootropic, has been extensively studied for its cognitive-enhancing potential. Its impact on memory improvement, focus, and brain health has been a subject of scientific exploration. While research on Piracetam's synergistic effects with other nootropics is limited, anecdotal reports suggest some effective combinations. However, it is crucial to approach nootropic use responsibly, considering individual variations and potential risks. Ethical considerations, responsible dosing, and expert guidance are paramount in the pursuit of cognitive enhancement. As the field continues to evolve, further research may shed light on the full extent of Piracetam's cognitive benefits and its interactions with other cognitive enhancers. Until then we are lucky that Piracetam is still obtainable for our personal exploration.


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