A Journey into Cellular Wellness With The Best Spermidine Supplements

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In the ever-evolving landscape of longevity and anti-aging supplements, there are a few well-known players that have garnered significant attention. Resveratrol and NMN are among the prominent names often associated with the quest for extended youthfulness. However, amidst these renowned contenders, a new star has emerged, capturing the fascination of researchers and health enthusiasts alike: spermidine supplement.

The discovery of spermidine dates back to the early 17th century when it was first identified in human semen. Its name derives from the Latin word “sperma,” meaning seed, highlighting its presence in reproductive fluids. However, subsequent research has revealed that spermidine is not exclusive to semen but is also found in cells throughout the body. It plays a crucial role in fundamental cellular processes, such as DNA synthesis, protein production, and cell growth regulation.

To assist you in navigating the realm of spermidine supplementation, we have curated a list of the top five spermidine supplements available in the market. These products have been selected based on factors such as quality, purity, absorption, manufacturing standards, and customer reviews. By choosing from this list, you can embark on your journey towards optimal cellular wellness with confidence.

Table of Contents

The Best Spermidine Supplements in 2023

Product Brand Doses Price

5 mg

Oxford Healthspan

1.2 mg

1 - 2 mg

Double Wood Suplements

10 mg


8 mg, 16 mg, 24 mg

What is Spermidine?

Spermidine molecular structure
Spermidine molecular structure

Spermidine is a polyamine compound that belongs to the class of organic compounds known as polyamines. It is naturally synthesized within cells through a series of enzymatic reactions involving the amino acid ornithine. These reactions occur in multiple steps and involve various enzymes.

While spermidine is synthesized within cells and can also be produced by certain gut bacteria through metabolic processes. The small amounts of spermidine can be found in foods like aged cheese, mushrooms, soybeans, and wheat germ, these levels may vary and might not provide significant health benefits.

As a result, spermidine supplements have gained popularity as a concentrated and convenient option to ensure an adequate intake of spermidine for potential health benefits. These supplements offer a standardized dosage, allowing individuals to enhance spermidine levels and support various cellular processes and overall well-being.

The Science Behind Spermidine

Spermidine plays vital roles in various cellular functions and processes, contributing to the overall health and well-being of cells. Some of its key roles include:

  1. Nucleic Acid Stabilization: Spermidine helps stabilize and maintain the structure of nucleic acids, including DNA and RNA. It binds to the negatively charged phosphate groups in DNA, promoting its stability and protecting it from damage.

  2. Protein Synthesis: Spermidine is involved in protein synthesis, which is crucial for cellular growth, repair, and maintenance. It helps in the initiation and elongation of protein synthesis, contributing to the production of functional proteins within cells.

  3. Cell Growth and Division: Spermidine is required for proper cell growth and division. It participates in processes such as cell cycle regulation and the formation of the mitotic spindle, which ensures accurate distribution of genetic material during cell division.

  4. Cell Death Regulation: Spermidine is involved in the regulation of programmed cell death, known as apoptosis. It helps maintain the balance between cell survival and cell death, contributing to proper tissue development and homeostasis.

"Spermidine has emerged as a natural autophagy inducer with potent anti-aging effects. Its ability to enhance cellular quality control mechanisms holds great promise for extending healthspan and preventing age-related diseases."
Dr. Frank Madeo
Professor of Molecular Biology, University of Graz, Austria
"Spermidine has been shown to improve cardiovascular health, extend lifespan, and protect against age-related cognitive decline. Its multifaceted benefits make it an intriguing compound for promoting overall health and well-being."
Dr. Valter Longo
Professor of Gerontology and Biological Sciences, University of Southern California, USA
running on a sunny day

Health Benefits of Spermidine

It’s worth noting that the levels of spermidine in the body can vary depending on several factors, including age, nutritional status, and overall health. Spermidine levels tend to decline with age, which has led to interest in spermidine supplementation as a means to maintain or restore adequate levels of this compound. Health benefits of spermidine are many and here’s one by one on which we’ll elaborate.

Autophagy Induction

Spermidine has been found to induce autophagy, a cellular process that plays a crucial role in maintaining cellular health and promoting longevity. Autophagy helps remove damaged or dysfunctional cellular components, such as proteins and organelles, thereby reducing cellular stress and improving overall cellular function. By promoting autophagy, spermidine may have the following impacts:

  • Longevity: Studies in various organisms, including yeast, flies, worms, and mice, have shown that spermidine supplementation can extend lifespan. It is believed that the induction of autophagy by spermidine contributes to these anti-aging effects.

  • Age-Related Diseases: Dysfunctional autophagy has been linked to the development of age-related diseases, such as neurodegenerative disorders and cardiovascular diseases. Spermidine’s ability to induce autophagy may have implications for reducing the risk or progression of these diseases by enhancing cellular health and reducing the accumulation of toxic proteins.

Cardiovascular Benefits

Spermidine has shown promising cardiovascular benefits and potential effects on blood pressure and heart health. Research in this area has revealed the following:

  • Blood Pressure Regulation: Studies have suggested that spermidine supplementation may help regulate blood pressure. Animal studies have demonstrated that spermidine can reduce blood pressure levels, possibly through its vasodilatory and antioxidant effects.

  • Cardiac Function: Spermidine has been found to improve cardiac function and protect against heart disease. It has shown benefits in reducing cardiac hypertrophy (enlargement of the heart) and preserving the structure and function of heart cells.

  • Spermidine and Mitochondrial Function: Recent scientific studies have shed light on the influence of spermidine on mitochondrial function. Spermidine has been found to promote mitochondrial biogenesis, which refers to the creation of new mitochondria within our cells. By increasing the number of mitochondria, spermidine can potentially enhance the energy production capacity of our cells.

Neuroprotective Effects

Spermidine supplementation has demonstrated neuroprotective effects, suggesting potential nootropic benefits for brain health and cognitive function:

  • Cognitive Function: Studies have shown that spermidine supplementation can improve cognitive function and memory. Animal research indicates that spermidine may enhance synaptic plasticity (the ability of synapses to strengthen or weaken over time), which is essential for learning and memory processes.

  • Neurodegenerative Disorders: Spermidine’s ability to induce autophagy may have implications for neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases. Autophagy helps clear toxic protein aggregates and damaged cellular components, potentially reducing the risk or progression of these disorders.

Anti-Inflammatory Properties

Spermidine exhibits anti-inflammatory properties, which may be beneficial for managing chronic inflammation:

  • Inflammatory Markers: Research has indicated that spermidine supplementation can reduce the production of pro-inflammatory molecules, such as cytokines and chemokines. By modulating these inflammatory markers, spermidine may help alleviate chronic inflammation.

  • Inflammatory Diseases: Animal studies have shown that spermidine can protect against inflammation-induced conditions, such as colitis and arthritis. It has demonstrated the potential to reduce inflammation and promote tissue repair.

Immune Function, Liver Health, etc.

  • Immune Function: Spermidine has been found to modulate immune responses and enhance immune function. It can stimulate the production of certain immune cells, promoting a robust immune response and potentially improving overall immune function.

  • Liver Health: Spermidine supplementation has shown protective effects against liver damage caused by various factors, such as alcohol consumption and oxidative stress. It exhibits antioxidant and anti-inflammatory properties, which contribute to its potential liver-protective effects.

Spermidine supplements available in 2023

It is essential to be cautious when selecting supplements, as many are not regulated by the FDA and may not meet quality standards. When considering spermidine, it is crucial to choose a reliable source.

In this article, we will discuss the top spermidine supplements available on the market. Each product on our list has undergone third-party testing to ensure quality and efficacy. We go the extra mile to ensure the supplements we recommend meet high standards.

In terms of absorption, there are different formulations and technologies used in spermidine supplements to enhance bioavailability and absorption. Here are a few examples:

  1. Spermidine Complexes: Some supplements use complex formulations where spermidine is combined with other compounds or carriers to improve its absorption. These complexes may enhance the stability and solubility of spermidine, allowing for better absorption in the body.

  2. Spermidine Liposomes: Liposomal formulations involve encapsulating spermidine within lipid vesicles called liposomes. Liposomes can protect spermidine from degradation and improve its absorption by facilitating its passage through cell membranes. This may result in increased bioavailability and enhanced cellular uptake of spermidine.

  3. Spermidine Sprays: Sprays offer an alternative delivery method for spermidine supplementation. These products typically contain a liquid formulation that is sprayed into the mouth, allowing for direct absorption through the oral mucosa. This bypasses the digestive system, potentially leading to faster absorption and utilization of spermidine.

  4. Spermidine Sublingual Tablets: Sublingual tablets are designed to be dissolved under the tongue, allowing the spermidine to be absorbed directly into the bloodstream through the sublingual mucosa. This method bypasses the gastrointestinal tract and may result in rapid absorption and improved bioavailability of spermidine.

It’s important to note that the effectiveness of different absorption-enhancing techniques may vary, and individual responses may differ. 

Spermidine dosage

The appropriate dosage of spermidine can vary depending on several factors, including age, health condition, and the specific purpose of supplementation. It is always recommended to consult with a healthcare professional or follow the instructions provided by the manufacturer for the recommended dosage.

There is no established standard dosage of spermidine due to limited clinical research and variations in product formulations. However, typical dosages range from 1 to 10 milligrams per day for general health maintenance.

Gluten-free spermidine supplements

Some spermidine supplements may contain gluten because spermidine is naturally present in wheat germ extract. Gluten-free spermidine supplements are formulated without any ingredients derived from gluten-containing grains like wheat, barley, or rye. This allows individuals with gluten sensitivities or celiac disease to enjoy the benefits of spermidine without worrying about gluten.

However, the best brands can offer gluten-free options by innovating the spermidine manufacturing process. You can find them in our list that follows.

High dose spermidine in Liposomal Delivery

#1 Purovitalis Spermidine

liposomal spermidine supplement

One-time purchase €99,95 | Subscribe & save €84,96 (60 caps / 60 day supply)

  • A unique blend of spermidine, zinc, D3, and B-vitamins
  • High Dose - 5mg Liposomal Spermidine per capsule
  • Regulate your body's natural cleansing process.
  • Feel more energetic and vital
  • Unflavoured and packed in HPMC (Vegan capsule)


Purovitalis Liposomal Spermidine Fusion is a comprehensive supplement that combines spermidine with essential nutrients like B-vitamins, zinc, and vitamin D3 to support vital processes in the body. What sets this supplement apart is its liposomal delivery system, which ensures maximum absorption and effectiveness by protecting the nutrients from digestion. With benefits such as immune system support, energy boost, and promotion of overall health and wellness, Purovitalis Liposomal Spermidine Fusion is an ideal choice for health-conscious individuals. The high dose of 5mg liposomal spermidine per capsule and the convenient, easy-to-take capsules make it a convenient option to support autophagy and enhance vitality.

Order Purovitalis spermidine

wholly food-derived from wheat germ extract

#2 Oxford Healthspan Primeadine Spermidine

Primeadine spermidine review

One-time purchase €85,00 | Subscribe & save €64,23 (60 tablets / 30 day supply)

    • Primeadine spermidine supplements are derived from 900mg of concentrated Japanese wheat germ extract
    • Each dose contains 1mg of supplemental spermidine, a tested and effective dosage for humans
    • The formulation undergoes rigorous testing to meet US and Japanese standards for potency and purity
    • The wheat germ extract is defatted to prevent the oils from going rancid, ensuring product quality
    • It contains a prebiotic fiber called FOS (fructooligosaccharides) derived from maltodextrin, which selectively feeds spermidine-producing bacteria in the gut
    • The supplements are enclosed in vegan-friendly, plant cellulose capsules (hypromellose)


Primeadine stands out as a top spermidine supplement due to its unique features and commitment to quality. Derived from food sources like wheat germ extract, Primeadine offers a natural advantage by providing a combination of nutrients along with spermidine. It goes beyond exogenous spermidine supplementation by including prebiotic fiber and resistant starch to support the production of spermidine-producing gut bacteria, promoting the body's natural spermidine production. Primeadine sets itself apart by eliminating cheap omega-6 oil commonly found in spermidine supplements, ensuring product stability and effectiveness. Manufactured in an FDA-approved facility and backed by the University of Oxford, Primeadine upholds rigorous quality standards. With its emphasis on clinical safety and a formula designed to enhance aesthetic properties and promote cellular health, Primeadine is gaining recognition as one of the leading spermidine sources in the world.

Order OHP spermidine

2x Strength CelVio® Complex with 30% more polyamines

#3 Longevity Labs SpermidineLife® Extra+

SpermidineLIFE extra+ REVIEW

One-time purchase $99.00 | Subscribe & save $89.00 (Delivery every 28 Days)

  • CelVio wheat-germ extract, Zinc, Thiamine, Hypromellose plant cellulose capsule, Acetylated Starch, Calcium Carbonate, Magnesium Stearate, Glycerol
  • Award-winning spermidine-rich wheat germ extract
  • Suitable for vegans and vegetarians
  • Free of artificial colors or flavors, lactose, nuts, and caffeine
  • 100% GMO-free product


SpermidineLife® Extra+ from Longevity Labs stands out for its overall quality and innovative approach. Developed in Austria, Longevity Labs utilizes a patented CelVio® complex, ensuring a consistent and pure water extraction without aggressive solvents or chemical drying.. Their natural manufacturing process combines spermidine with other polyamines and micronutrients, avoiding synthetic ingredients. With patents, awards, and a strong reputation, Longevity Labs is a top-quality spermidine company. Their Extra+ version offers a higher dose of spermidine, although still less than 2mg overall. While cost may be a factor, SpermidineLife® Extra+ is a recommended choice among reputable options. Spermidine Life focuses on promoting cellular health and longevity by activating the autophagy process and enhancing brain health and immunity. Widely used by international research teams and trusted in clinical research, SpermidineLife® Extra+ offers the same high-quality spermidine as used in academic studies.

Order Life Extra+ spermidine

Derived from Putrescine, great value for money

#4 Double Wood Supplements Spermidine

Double Wood Supplements Spermidine review

One-time purchase $ 39.95 (120 x 5 mg capsules) | Buy Multiple Bottles and Save! Spermidine Double Pack - $74.95 | Spermidine Triple Pack - $99.95

  • With 10mg of spermidine per serving, it’s the strongest supplement on this list
  • Putrescine, Rice Flour, Plant Cellulose Capsule
  • Recommended starting dosage of 1-2 capsules (5-10 mg), which can be increased to 2-4 capsules (10-20 mg) if desired
  • Manufactured and tested for safety in the USA


Double Wood Spermidine is an affordable option for those interested in trying spermidine supplements. Manufactured in the USA, the company provides testing results for every batch, ensuring transparency and trust. While it offers the highest dose of spermidine at a lower upfront cost, questions remain regarding its bioavailability and the purity of the spermidine. Despite lacking the scientific staff and comprehensive design of other top brands, Double Wood Spermidine remains a suitable choice for individuals on a budget seeking to enhance autophagy and cellular health.

Order Double Wood spermidine

Wheat germ extract high-quality spermidine

#5 DoNotAge.org Spermidine

Donotage spermidine review

One-time purchase 45.00 (60 caps) | 269.00 (366 caps)

  • Wheat-gram extract, Zinc, Cellulose
  • A strong product with 4x greater potency in a single capsule
  • Guarantees the delivery of pure and maximum-quality spermidine without degradation


Do Not Age (DNA) Spermidine, offered by a reputable UK-based vendor, is known for manufacturing high-quality and affordable supplements. Their product stands out with its impressive potency, providing 4mg of spermidine from just 400mg of wheat germ extract, along with 1mg of Zinc Picolinate. Do Not Age ensures the quality and purity of their spermidine by adhering to ISO9001 and GMP standards, preventing oxidation and degradation of the supplement. The company's commitment to research and their global shipping options, along with their certificates of analysis from third-party testing labs, further solidify their reputation in the field of healthy aging.

Order DNA spermidine


In conclusion, spermidine emerges as a captivating compound with diverse potential benefits for health and aging. From its roles in cellular function to its autophagy-inducing properties and anti-inflammatory effects, spermidine holds promise in promoting longevity, supporting cognitive health, protecting against diseases, and fostering overall well-being. As research continues to uncover the fascinating aspects of spermidine, it becomes evident that harnessing its power through supplementation may open new avenues for enhancing our journey towards a healthier and vibrant life.

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