Huperzine-A is a naturally occurring compound purified from the plant called Huperzia serrata. It is best known as an inhibitor of an acetylcholinesterase (AChE) enzyme that breaks down the ‘learning neurotransmitter’ acetylcholine.
By preventing the breakdown, Huperzine-A boosts the levels of available acetylcholine which plays the role in forming new memories, reasoning, concentration, cognition, and neuroplasticity. Huperzine-A is thus used as memory and learning enhancer and for age-related memory impairment. It also works as an antioxidant by reducing the free radical damage of the brain cell and boosts the activity of other brain antioxidants.
It also plays a neuroprotective role by protecting brain cells from glutamate toxicity and increases nerve growth factor levels in the brain thus preventing neurodegenerative diseases like Alzheimer. Researchers are investigating Huperzine-A for protection against chemical warfare nerve agent poisoning.
It should be said that because of the long half-life most neuro-hackers prefer cycling.
- When taken in very large doses huperzine-A can cause nausea, vomiting, and diarrhea, slurred speech, muscle twitching, drooling, incontinence, elevated blood pressure, and a slow heart rate.
- Huperzine-A may cause ‘transient gastrointestinal dysfunction and elevations of ALT