Huperzine A


Huperzine A 1% Powder

QUANTITY PER BOTTLE: 1g, 5g, 10g | SERVINGS PER BOTTLE: 50 Servings, 250 Servings, 500 Servings

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Huperzine A is a naturally occurring compound purified from the plant called Huperzia serrata. It is best known as an inhibitor of an acetylcholinesterase (AChE) enzyme that breaks down the ‘learning neurotransmitter’ acetylcholine.

By preventing the breakdown, huperzine A boosts the levels of available acetylcholine which plays the role in forming new memories, reasoning, concentration, cognition, and neuroplasticity. Huperzine A is thus used as memory and learning enhancer that may also help to protect the brain by reducing free radicals and oxidative stress. As well as to enhance the work of other free radical scavengers.

It also plays a neuroprotective role by protecting brain cells from glutamate toxicity and increases nerve growth factor levels in the brain. Researchers are also investigating huperzine A for protection against chemical warfare nerve agent poisoning.

It should be said that because of the long half-life most neuro-hackers prefer cycling. Cycling of huperzine A tends to be used since it can remain in the body for quite some time (half-life of 10-14 hours), and although a ‘cycle’ of huperzine A tends to last 2-4 weeks followed by a break the optimal cycle length is not yet known.




Also known as

Chinese club moss (Huperzia serrata), HupA, Huperzina A, Huperzine, Huperzine-A, Selagine, Sélagine, Qian Ceng Ta

Side effects

Supplementation of huperzine A tends to be in the range of 50-200mcg daily, and while this can be divided into multiple dosages throughout the day it tends to be taken at a single dose. Supplementation of huperzine A does not require food to be coingested with it and can be taken in a fasted state.

  • When taken in very large doses huperzine A can cause nausea, vomiting, and diarrhea, slurred speech, muscle twitching, drooling, incontinence, elevated blood pressure, and a slow heart rate.
  • Huperzine A may cause ‘transient gastrointestinal dysfunction and elevations of ALT


Further information

Another interesting thing about huperzine A, is that via inhibiting the G4 Isoform of Acetylcholineesterase, it causes increased activation of Alpha 7 Nicotinic Acetylcholine receptors. These receptors regulate inflammatory pathways in the brain.

Nootropics Depot offers Huperzine capsules that contain 200 mcg of huperzine A, which according to research is one of the most efficacious dosages huperzine A. 

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